Σάββατο 27 Οκτωβρίου 2018
Response to “Letter to the editor regarding ‘Improvement of local microcirculation through intermittent Negative Pressure Wound Therapy (NPWT)’”
Publication date: Available online 26 October 2018
Source: Journal of Tissue Viability
Author(s): A. Sogorski, J. Kolbenschlag
Dectin-2-mediated signaling leads to delayed skin wound healing through enhanced neutrophilic inflammatory response and neutrophil extracellular traps formation
Dendritic cell-associated C-type lectin-2 (Dectin-2) recognizes fungal polysaccharides, including α-mannan. Dectin-2-mediated recognition of fungi, such as Candida albicans, leads to NF-κB activation, which induces production of inflammatory cytokines. However, Dectin-2's role in skin wound healing remains unclear. In this study, we sought to determine how Dectin-2 deficiency and the administration of α-mannan affected the wound healing process. Full-thickness wounds were created on the backs of wild type (WT) C57BL/6 and Dectin-2-deficient (KO) mice.
Reconstituting human cutaneous regeneration in humanized mice under endothelial cell therapy
Much of our understanding of human biology and the function of mammalian cells in tissue regeneration have been derived from mechanistically and genetically manipulated rodent models. However, current models examining epidermal wound repair fail to simultaneously address both the cross-species mechanistic and immunogenic differences. Herein, we describe a multifaceted approach intended to better recapitulate human skin recovery in rodent models. First, immunodeficient NSG mice were intravenously inoculated with human hematopoietic stem cells to become in essence, humanized, and capable of initiating an adaptive immune response.
The AHR regulates metabolic reprogramming to promote SIRT1-dependent keratinocyte differentiation
Activation of the transcription factor, the aryl hydrocarbon receptor (AHR), in normal human epidermal keratinocytes (NHEKs) increased AHR binding in the promoters of the glucose transporter, SLC2A1, and the glycolytic enzyme, enolase 1 (ENO1). This increased chromatin binding corresponded with AHR-dependent decreases in levels of SLC2A1 and ENO1 mRNA, protein and activities. Studies of the ENO1 promoter showed activation of the AHR decreases the transcription of ENO1. Glycolysis was lowered by activation of the AHR as measured by decreases in glucose uptake and the production of pyruvate and lactate.
Production of Extracellular Adenosine by CD73+ Dendritic Cells is Crucial for Induction of Tolerance in Contact Hypersensitivity Reactions
Dendritic cells (DC) express the ecto-5'-nucleotidase CD73 that generates immunosuppressive adenosine (Ado) by dephosphorylation of extracellular adenosine mono- and -diphosphate. To investigate whether CD73-derived Ado has immune suppressive activity, 2,4-dinitrothiocyanobenzene (DNTB) was applied to skin of wildtype (WT) or CD73 deficient (CD73-/-) mice, followed by sensitization and challenge with 2,4-dinitrofluorobenzene (DNFB). In this model we demonstrate induction of tolerance by DNTB against DNFB only in W T but not in CD73-/- mice.
Adiponectin enhances human keratinocyte lipid synthesis via SIRT1 and nuclear hormone receptor signaling
Adiponectin is known to have beneficial effects on lipid and insulin metabolism, wound healing, and cellular senescence, but its effect on skin barrier formation remains unknown. We investigated the effects of adiponectin on keratinocyte lipid synthesis with respect to skin barrier function. Lipid staining revealed an adiponectin-mediated increase in keratinocyte intracellular and reconstructed epidermal lipid content. Moreover, significant increases in the levels of ceramide and its downstream metabolites (sphingosine and sphingosine-1-phosphate) following adiponectin stimulation were detected using liquid chromatography–mass spectrometry.
Morphological Plasticity of Human Melanoma Cells is Determined by Nanoscopic Patterns of E- and N-Cadherin Interactions
Loss of E-cadherin and concomitant up-regulation of N-cadherin is known as the cadherin switch and has been implicated in melanoma progression. Mechanistically, homophilic ligation of N-cadherin-expressing melanoma cells with N-cadherin presented within the micro-environment is thought to facilitate invasion. However, the biophysical aspects governing molecular specificity and function of such interactions remain unclear. By using precisely defined nano-patterns of N- or E-cadherin (with densities tunable by more than one order of magnitude, from 78 to 1,128 ligands/μm2), we analyzed adhesion and spreading of six different human melanoma cell lines with distinct constitutive cadherin expression patterns.
Chemoprotective effects of dietary grape powder on ultraviolet B radiation-mediated skin carcinogenesis in SKH-1 hairless mice
Skin cancer is the most frequently diagnosed cancer in the US, and solar ultraviolet (UV) radiation is an established causative factor for ∼90% of these cases. Despite efforts aimed at UV protection, including use of sunscreen and clothing, annual cases of skin cancers continue to rise. Here, we report that dietary grape powder (GP) mitigates UVB-mediated skin carcinogenesis in SKH-1 hairless mouse model. Employing a UVB initiation-promotion protocol, where mice were exposed to 180 mJ/cm2 UVB 2x/week for 28 weeks, we determined the effects of GP-fortified diet (3% or 5%) on skin carcinogenesis.
Phenotypic Spectrum of Epidermolysis Bullosa, the Paradigm of Syndromic Versus Non-Syndromic Skin Fragility Disorders
The heritable forms of epidermolysis bullosa (EB), a phenotypically heterogeneous group of skin fragility disorders, is currently associated with mutations in as many as 21 distinct genes. EB is primarily a disorder affecting the epithelial layers of skin and mucous membranes, without extracutaneous manifestations, and thus being non-syndromic. However, recent demonstrations of skin blistering in the spectrum of EB in multisystem disorders with single gene defects highlight the concept of syndromic EB.
Present and future perspective of photodynamic therapy for cutaneous squamous cell carcinoma
Photodynamic therapy may benefit patients with cutaneous squamous cell carcinoma who are not eligible for surgery. Photodynamic therapy can be modified to provide better effect by use of microneedles or laser, by use of intralesional injection of photosensitizers instead of topical application, by use of nanoparticles or by use of adjuncts.
Mortality and Chronic Disease Risk Associated With Poor Life Satisfaction: A Population-Based Cohort Study
Abstract
Life satisfaction is increasingly recognized as an important determinant of health; however, prospective population-based studies are limited. The objective was to estimate the risk of developing chronic disease and death according to life satisfaction among a population-based cohort in Ontario, Canada (N = 73,904). The cohort included three pooled cycles of the Canadian Community Health Survey (2003-2008), linked to 6 years of follow-up (to 2015) using population-based health databases and validated disease-specific registries. The databases capture incident and prevalent diabetes, cancer, chronic obstructive pulmonary disease, heart disease and mortality. Multivariable Cox proportional hazard models were used to estimate hazards of incident chronic disease and mortality, adjusting for sociodemographic, behavioural and clinical confounders including age, sex, comorbidity, mood disorder, smoking, alcohol consumption, physical activity, BMI, immigrant status, education, and income. In the fully adjusted models, risk of both death and incident chronic disease was highest for those most dissatisfied with life (mortality HR = 1.59, 95% CI: 1.15, 2.19; chronic disease HR = 1.74, 95% CI: 1.19, 2.56). In this population-based cohort, poor life satisfaction is an independent risk factor for incident chronic disease and mortality, supporting the idea that interventions and programs that improve life satisfaction will impact population health.First case of proven invasive pulmonary infection due to Trichoderma longibrachiatum in a neutropenic patient with acute leukemia
Publication date: Available online 26 October 2018
Source: Journal de Mycologie Médicale
Author(s): M. Sautour, M.L. Chrétien, S. Valot, I. Lafon, L. Basmaciyan, C. Legouge, T. Verrier, B. Gonssaud, H. Abou-Hanna, F. Dalle, D. Caillot
Abstract
Trichoderma species are saprophytic filamentous fungi that can be found all over the word. These fungi show increasing medical importance as opportunistic human pathogens, particularly in immunocompromised patients. Invasive infections due to Trichoderma are rare and definitive diagnosis is complex to achieve because of the lack of specific diagnosis tools. We report in this work the first proven case of invasive pulmonary infection due to T. longibrachiatum in a 69-year-old white male with hematologic malignancy. The patient was successfully treated initially with voriconazole alone followed by a combination of voriconazole and caspofungine.
Dear Dr. Dermatoethicist: Exam of the Future or Exam of Future Cheating? Ethical Issues Surrounding the American Board of Dermatology’s New Certification Examination
Publication date: Available online 27 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): Reid A. Waldman, Jane M. Grant-Kels
Non-cultured epidermal suspension grafting using suction blisters as donor tissue for vitiligo
Publication date: Available online 27 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): Andrea Tovar-Garza, Jorge A. Hinojosa, Linda S. Hynan, Amit G. Pandya
Benign subungual epidermoid inclusions
Publication date: Available online 27 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): Josette André, Eckart Haneke
Reply to "Benign subungual epidermoid inclusions"
Publication date: Available online 27 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): Amélie Boespflug, Sébastien Debarbieux, Lauriane Depaepe, Brigitte Chouvet, Delphine Maucort-Boulch, Stéphane Dalle, Brigitte Balme, Luc Thomas
A Phase 2, Randomized Dose-Finding Study of Tapinarof (GSK2894512 Cream) for the Treatment of Plaque Psoriasis
Publication date: Available online 26 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): Kevin Robbins, Robert Bissonnette, Tomoko Maeda-Chubachi, Li Ye, Johnny Peppers, Kelly Gallagher, John E. Kraus
Abstract
Background
There is a significant need for novel, safe and efficacious topical treatments for psoriasis.
Objective
We assessed the safety and efficacy of tapinarof in a new cream formulation in 2 concentrations and 2 application frequencies in adults with psoriasis.
Methods
Double-blind, vehicle-controlled, randomized, 6-arm trial (1:1:1:1:1:1) in adults, with psoriasis with body surface (BSA) involvement ≥1% and ≤15% and PGA ≥2 at Baseline. Primary endpoint included PGA = 0 or 1 at Week 12, and a 2-grade improvement from Baseline. Additional analyses included PASI75 and mean percent change in PASI and BSA.
Results
Treatment success defined by PGA 0 or 1 and a 2-Grade Improvement at Week 12 were statistically significantly higher (at a 0.05 significance level) in the tapinarof groups than the vehicle groups: (65% [1%BID]; 56% [1%QD]; 46% [0.5%BID]; 36% [0.5%QD]; 11% [vehicle BID], and 5% [vehicle QD]) and was maintained for 4 weeks post-treatment. Treatment-emergent adverse events (TEAEs) were higher with tapinarof (85/152 patients [56%] compared to vehicle 19/75 patients [25%]) and mild-to-moderate in intensity. Severe TEAEs were reported in all tapinarof groups except 0.5% QD.
Limitations
Large confirmation trials are needed.
Conclusions
Tapinarof cream is efficacious and well tolerated in adult patients with psoriasis.
Response to “A relapsing peeling of oral mucosa”
Publication date: Available online 26 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): Andrea D. Maderal, Paul Lee Salisbury, Joseph L. Jorizzo
Histologic predictors of invasion in partially biopsied lentigo maligna melanoma
Publication date: Available online 26 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): I. Aouidad, C. Fargeas, P. Romero, J.F. Sei, V. Chaussade, A. Beauchet, T. Clerici, U. Zimmermann, P. Saiag, E. Funck-Brentano
Classic Dermatological Tools: Foreign Body Removal with Punch Biopsy
Publication date: Available online 26 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): Jesus Alberto Cardenas-de la Garza, Adrian Cuellar-Barboza, Jesus Ancer-Arellano, Cesar Jair Ramos-Cavazos, Osvaldo Tomas Vazquez-Martinez, Jorge Ocampo-Candiani
Markers of systemic involvement and death in hospitalized cancer patients with severe cutaneous adverse reactions
Publication date: Available online 26 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): Shoko Mori, Alanna Hickey, Stephen W. Dusza, Mario E. Lacouture, Alina Markova
Abstract
Background
Severe cutaneous adverse reactions (SCARs) are frequent in inpatient oncology. Early intervention may reduce morbidity, mortality, and hospitalization costs, however current clinical and histologic features are unreliable SCAR predictors. There is a need to identify rational markers of SCARs that could lead to effective therapeutic interventions.
Objective
To characterize the clinical and serologic features of hospitalized patients with cancer who developed SCARs.
Methods
Retrospective review of 49 hospitalized cancer patients with a morbilliform rash and recorded testing for serum cytokines (IL-6, IL-10, TNF-α) or elafin, and prior dermatology consultation. Patients were categorized as having a 'simple' morbilliform rash without systemic involvement or 'complex' morbilliform rash with systemic involvement.
Results
Fifteen out of 49 patients (30.6%) were deceased at 6 months from time of dermatologic consultation. Elafin, IL-6, and TNF-α were significantly higher in patients who died compared to patients who were still alive at 6 months. IL-6 and IL-10 were significantly higher in patients with a drug-related 'complex' rash.
Limitations
Retrospective design, limited sample size, high-risk patient population.
Conclusion
In cancer patients with SCARs, elafin, IL-6, and TNF- α may predict a poor outcome. Agents directed towards these targets may represent rational treatments for the prevention of fatal SCARs.
A relapsing peeling of oral mucosa
Publication date: Available online 26 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): M.A. Chessa, E. Dika, G. Carlotta, B. Carlotta, A. Patrizi
Les prothèses mammaires : n’oublions pas les implants en sérum physiologique
Publication date: Available online 26 October 2018
Source: Annales de Chirurgie Plastique Esthétique
Author(s): D. Boccara, N. Malca, K. Serror, M.-C. Dutot, M. Chaouat, M. Mimoun
Évaluation et impact du respect du référentiel ESMO sur la prise en charge des lésions des tissus mous, étude menée au centre de référence de Lorraine
Publication date: Available online 26 October 2018
Source: Annales de Chirurgie Plastique Esthétique
Author(s): J. Genet, J. Salleron, A. Leroux, J.-L. Verhaeghe, E. Simon
Résumé
Introduction
Malgré les recommandations régulières émises par l'European Society for Medical Oncology (ESMO), la prise en charge des lésions des tissus mous est encore trop souvent insuffisante, pouvant aggraver le pronostic fonctionnel mais aussi vital du patient.
Méthode
Une étude a été menée au centre de référence de Lorraine. Tous Les patients inscrits dans la base de données NetSarc, au décours d'un passage en RCP, entre le 1er janvier 2010 et le 1er septembre 2016 ont été inclus. Les critères de conformité de prise en charge ont été établis en utilisant le dernier référentiel ESMO 2014, permettant de distinguer deux groupes, « conforme » et « non conforme » aux recommandations. Une première analyse comparative a été faite entre les deux groupes toutes lésions confondues. Puis une seconde uniquement sur les sarcomes.
Résultats
Au total, 445 patients présentant une lésion des tissus mous ont été inclus, 344 cas ont été traités selon les recommandations de l'ESMO, soit un taux de conformité de 77,3 %% (IC95 % : 73,4 %, 81,2 %). La conformité était meilleure pour le centre de référence que pour les structures périphériques (p < 0,001), avec des taux de conformité respectivement de 88,7 % et 51,6 %. Sur les 247 sarcomes, nous retrouvions un taux de résection R0 meilleur en cas de dossiers conformes 55 % contre 18 % (p < 0,001). Les taux de R1 étaient de 34 % contre 56 % et R2 de 11 contre 26 %. La survie n'était pas liée de manière significative à l'observance des recommandations dans l'analyse univariée. Après ajustement sur les facteurs pronostiques potentiels, en analyse multivariée, les résultats étaient similaires.
Conclusion
Le respect des recommandations de l'ESMO, permet d'améliorer la qualité de l'exérèse chirurgicale des sarcomes et évite les gestes chirurgicaux inappropriés.
Summary
Introduction
Despite regular recommendations issued by the European Society for Medical Oncology (ESMO), patients faced still too often inadequate care with a direct influence on prognosis.
Methods
A retrospective study was carried out at the Competence center in Lorraine Area. Patients registered in the NetSarc database between 1st, 2010 and September 1st, 2016 were included. Compliance criteria were established using the latest ESMO 2014 referential. Two groups "conforming" and "non conforming" were analyzed. A first analyze about all of the soft tissue lesion and a second only about sarcomas.
Results
In total, 445 patients were eligible, 344 cases were treated according to the ESMO guidelines, giving a 77.3% conformity rate (95% CI: 73.4%, 81.2%). Compliance was better for the competence center than district hospitals (P < 0.001), with compliance rates of 88.7%, and 51.6%, respectively. Among the 247 sarcomas, we found a R0 resection rate better according to the ESMO guideline, 55% against 18% (P < 0.001). R1 rates were 34% vs. 56% and R2 11 vs. 26% disease free survival was not related significantly to the observance of recommendations in the univariate analysis. After adjustment on potential DFS prognostic factors, in the multivariate analysis, the results were similar.
Conclusion
Compliance with the ESMO guidelines, through appropriate management, improves the quality of surgical excision for sarcomas and avoids non-corresponding surgical gestures.
Pigmentation du palais dur sous imatinib
Publication date: Available online 27 October 2018
Source: Annales de Dermatologie et de Vénéréologie
Author(s): N. Kluger, P. Cassier, N. Ruffion
Albumin Plasma Exchange For Life Threatening Angioedema With Normal C1-Inhibitor
Publication date: Available online 26 October 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Danny M. Cohn, Sacha S. Zeerleder, Joost C.M. Meijers, Erik S.G. Stroes, Marcel Levi
Pricking Away At Penicillin Allergy with a Dedicated Outpatient Clinic
Publication date: Available online 26 October 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Renee Kleris, Monica Tang, Cristine Radojicic, Patricia L. Lugar
Tumor de lento crecimiento en el cuero cabelludo. Diagnóstico y comentario
Publication date: November 2018
Source: Piel, Volume 33, Issue 9
Author(s): Sofia Lucas-Truyols, Javier Sabater-Abad, Josefina San Juan Jiménez
Telangiectasias adquiridas y progresivas. Diagnóstico y comentario
Publication date: November 2018
Source: Piel, Volume 33, Issue 9
Author(s): Elisabet Amores-Martín, Gemma Melé-Ninot, Maria Teresa Fernández-Figueras
Utilidad de las pruebas epicutáneas en el estudio de las reacciones cutáneas a tatuajes
Publication date: November 2018
Source: Piel, Volume 33, Issue 9
Author(s): Juan Francisco Silvestre Salvador, Iris Gónzalez Villanueva
Food-grade gene transformation system constructed in Lactobacillus plantarum using a GlmS-encoding selection marker
Abstract
Food-grade gene expression systems in lactic acid bacteria enable production of functional proteins or product testing without antibiotic requirement. Here, we expanded the available selection markers by developing a novel food-grade genetic transformation system for Lactobacillus plantarum WCFS1 using the glucosamine-6-phosphate synthase gene (glmS1). A glmS-vector pSIPH497 was constructed by replacing the erythromycin resistance gene (erm) with L. plantarum glmS1 under control of the PldhL promoter from WCFS1. The selection efficiency and stability of the glmS-vector were shown to be comparable to those of the erm-based plasmid. Moreover, using mCherry expression as a reporter gene, we showed the feasibility of the system for producing foreign proteins. This food-grade host/vector system will provide an effective and safe technique for the application of lactic acid bacteria in the food and medical industries. Furthermore, this study provides a useful strategy for developing food-grade selection markers in other host/vector systems.Can I still eat it? Using problem-based learning to test the 5-second rule and promote scientific literacy
Abstract
Defining appropriate student learning outcomes for general education science courses is a daunting task. We must ask ourselves how to best prepare our students to understand the role of science in their lives and in society at large. In the era of social media and armchair experts, life-changing scientific advancements such as vaccination are being dismissed or actively resisted, emphasizing the critical need to teach science literacy skills. One active classroom method known as problem-based learning promotes self-motivated learning and synthesis skills that, when applied in a science-literacy context, can provide students with the ability to generate informed opinions on new scientific advances throughout their lifetime. This piece describes one such problem-based course, designed to tackle the scientific basis (or lack thereof) of the 5-second rule for eating food dropped on the floor. In this course, first year students experimentally engage this issue, while also applying their developing skill set to sort out scientific controversies such as vaccine safety and genetically modified foods.N-acetylmannosamine (ManNAc) supports the growth of Borrelia burgdorferi in the absence of N-acetylglucosamine (GlcNAc)
Abstract
Borrelia burgdorferi, the causative agent of Lyme disease, lacks the ability to biosynthesize many essential nutrients de novo, including N-acetylglucosamine (GlcNAc). This amino sugar is required for cell wall synthesis, and is a component of the complex growth medium used for in vitro propagation. When cultured without free GlcNAc, B. burgdorferi cells exhibit a unique biphasic growth pattern. We hypothesized that genes involved in the GlcNAc starvation response would be differentially expressed when compared to cells cultured in complete medium, and investigated this using transcriptomics. Twenty-one genes were differentially regulated in wild-type and starvation-adapted cells cultured without GlcNAc compared to wild-type cells cultured with GlcNAc. Of those, three genes involved in carbohydrate utilization were upregulated: bbb04 (chbC) encoding a subunit of the chitobiose transporter, bb0629 (fruA-2) encoding a putative carbohydrate transporter and bb0644 (nanE) encoding a putative GlcNAc-6-phosphate-2-epimerase predicted to catalyze the conversion of N-acetylmannosamine-6-phosphate (ManNAc-6-P) to GlcNAc-6-P. Quantitative RT-PCR was used to confirm differential expression of select genes, and substitution of free GlcNAc with free ManNAc resulted in growth to high cell density, suggesting B. burgdorferi cells can utilize free ManNAc for cell wall synthesis and energy production.Síndrome de Ehlers-Danlos clásico: hallazgos clínicos y ecográficos
Publication date: Available online 26 October 2018
Source: Actas Dermo-Sifiliográficas
Author(s): M. Herrero-Moyano, L. Noguera-Morel, A. Torrelo, A. Hernández-Martín
Aclaración sobre el artículo «Púrpura bullonecrótica de distribución esporotricoide por Scedosporium apiospermum»: desenlace y nueva presentación clínica
Publication date: Available online 26 October 2018
Source: Actas Dermo-Sifiliográficas
Author(s): J. Company-Quiroga, S. Alique-García, C. Martínez-Morán, J. Borbujo
Úlceras en abdomen
Publication date: Available online 26 October 2018
Source: Actas Dermo-Sifiliográficas
Author(s): M.I. Martínez-González, S. Goula-Fernández, R. González-Pérez
Two cases of primary cutaneous nocardiosis caused by intralesional injection
Dermatologic Therapy, Volume 0, Issue ja, -Not available-.
GEOGRAPHIC TONGUE THAT RESPONDS TO THE TREATMENT OF PREGABALIN: CAN IT BE A NEW TREATMENT CHOICE?
Dermatologic Therapy, Volume 0, Issue ja, -Not available-.
From ontic structural realism to metaphysical coherentism
Abstract
The present paper argues that the typical structuralist claims according to which invariances, symmetries and the like are fundamental – especially in physics – should not be understood in terms of physical relations being fundamental. Rather, they should be understood in terms of 'metaphysical coherentism' - the idea that object-like parts of reality exhibit symmetric relations of ontological dependence. The view is developed in some detail, in particular by showing that i) symmetric ontological dependence does not necessarily lead to uninformative metaphysical explanations, and ii) metaphysical coherentism strikes the best balance between the requirements of naturalism and those of theoretical consistency – especially in view of the difficulties that structuralists seem to have in accounting for all state-independent properties of particles in relational terms. On this basis, the coherentist picture is applied to the interpretation of the quantum domain, and contrasted with extant varieties of structuralism, of both the eliminative and the non-eliminative sort, and holism.
The humanistic and economic burden of chronic wounds: A systematic review
Wound Repair and Regeneration, Volume 0, Issue ja, -Not available-.
Renal dysfunction aggravated impaired cutaneous wound healing in diabetic mice
Wound Repair and Regeneration, Volume 0, Issue ja, -Not available-.
Photodynamic therapy for actinic keratosis of the forehead and scalp: a randomized, controlled, phase II clinical study evaluating the non‐inferiority of a new protocol involving irradiation with a light‐emitting, fabric‐based device (the Flexitheralight protocol) compared with the conventional protocol involving irradiation with the Aktilite CL 128 lamp
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro‐fibrotic changes in linear morphoea fibroblasts
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Diverse assays from a single skin punch biopsy to assess topical drug intervention
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Effect of secukinumab on clinical activity and disease burden of nail psoriasis: 32‐week results from the randomized placebo‐controlled TRANSFIGURE trial
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Pyoderma gangrenosum and its impact on quality of life: a multicentre, prospective study
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Patient reported outcome measures for facial skin cancer: A systematic review and evaluation of the quality of their measurement properties
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Letter to the Editor in reference to: Expression of 15‐lipoxygenase‐1 in Merkel cell carcinoma is linked to advanced disease
Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.
Reducing observation time in children post‐adenoidectomy
Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.
Εγγραφή σε:
Αναρτήσεις (Atom)
-
Does CBD Oil Lower Blood Pressure? This article was originally published at SundayScaries." Madeline Taylor POSTED ON January 13, 20...
-
https://www.youtube.com/watch?v=DFOhpBjLqN4&t=1s , Η ΘΕΡΑΠΕΙΑ ΓΙΑ ΟΛΕΣ ΤΙΣ ΑΣΘΕΝΕΙΕΣ 1 Περιεχόμενα Σύντομο βιογραφικό Πρόλογος μεταφραστ...
-
Publication date: Available online 28 September 2017 Source: Actas Dermo-Sifiliográficas Author(s): F.J. Navarro-Triviño
