Abstract Background The study aimed to evaluate the permanence of resin and enamel remains on lingual brackets at the end of orthodontic treatment and after the debonding procedure. The evaluation of resin remnants on customized lingual brackets bases has never done before in other studies because they are curved, and traditional techniques are not applicable. ...
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Related ArticlesAnti-epidermal growth factor receptor therapy for glioblastoma in adults. Cochrane Database Syst Rev. 2020 May 12;5:CD013238 Authors: Lee A, Arasaratnam M, Chan DLH, Khasraw M, Howell VM, Wheeler H Abstract BACKGROUND: Glioblastoma is an uncommon but highly aggressive type of brain tumour. Significant gains have been achieved in the molecular understanding and the pathogenesis of glioblastomas, however clinical improvements are difficult...
Wed May 13, 2020 14:17
Related ArticlesMicroRNA-18a induces epithelial-mesenchymal transition like cancer stem cell phenotype via regulating RKIP pathway in pancreatic cancer. Ann Transl Med. 2020 Apr;8(7):433 Authors: Kang H, Ma D, Zhang J, Zhao J, Yang M Abstract Background: Pancreatic cancer is a devastating invasive disease. Understanding the molecular mechanism of metastasis of this cancer is basis for its treatment and prevention. Methods: Pancreatic cancer...
Wed May 13, 2020 14:17
Related ArticlesSjögren-Larsson syndrome: The mild end of the phenotypic spectrum. JIMD Rep. 2020 May;53(1):61-70 Authors: Staps P, van Gaalen J, van Domburg P, Steijlen PM, Ferdinandusse S, den Heijer T, Seyger MMB, Theelen T, Willemsen MAAP Abstract Sjögren-Larsson syndrome (SLS) is a rare inborn error of lipid metabolism. The syndrome is caused by mutations in the ALDH3A2 gene, resulting in a deficiency of fatty aldehyde dehydrogenase. Most patients...
Wed May 13, 2020 14:17
Related ArticlesPast, present, and future of palliative care in emergency medicine in the USA. Acute Med Surg. 2020 Jan-Dec;7(1):e497 Authors: George N, Bowman J, Aaronson E, Ouchi K Abstract The emergency department (ED) provides immediate access to medical care for patients and families in times of need. Increasingly, older patients with serious illness seek care in the ED, hoping for relief from symptoms and suffering associated with advanced...
Wed May 13, 2020 14:17
Related ArticlesVisual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research. Neuroophthalmology. 2020 Jun;44(3):139-147 Authors: Anderson DE, Holstein SA, Kedar S Abstract Chemotherapy-related neurotoxicity (CRNT) is an emerging public health concern. Visual pathway degeneration may be a symptom of CRNT. We surveyed the current literature for evidence of visual pathway degeneration in cancer patients...
Wed May 13, 2020 14:17
Related ArticlesSKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer. J Contemp Brachytherapy. 2020 Apr;12(2):105-110 Authors: Lancellotta V, Guinot JL, Fionda B, Rembielak A, Di Stefani A, Gentileschi S, Federico F, Rossi E, Guix B, Chyrek AJ, Meritxell A, Villalba SR, Colloca GF, Dinapoli N, Masciocchi C, Lenkowicz J, Capocchiano ND, Damiani...
Wed May 13, 2020 14:17
Related ArticlesNovel Strategies in Immune Checkpoint Inhibitor Drug Development: How Far Are We From the Paradigm Shift? Br J Clin Pharmacol. 2020 May 11;: Authors: Watson GA, Doi J, Hansen AR, Spreafico A Abstract The development of immune checkpoint inhibitors (ICI) represents a major milestone in immune-oncology. Over the years these agents have demonstrated efficacy in an increasing array of malignancies. Despite this success however, significant...
Wed May 13, 2020 13:16
Related ArticlesAnnual report of the Japanese Breast Cancer Society registry for 2016. Breast Cancer. 2020 May 11;: Authors: Kubo M, Kumamaru H, Isozumi U, Miyashita M, Nagahashi M, Kadoya T, Kojima Y, Aogi K, Hayashi N, Tamura K, Asaga S, Niikura N, Ogo E, Iijima K, Tanakura K, Yoshida M, Miyata H, Yamamoto Y, Imoto S, Jinno H Abstract The Japanese Breast Cancer Society (JBCS) registry began data collection in 1975, and it was integrated into National...
Wed May 13, 2020 13:16
Related ArticlesThe efficacy of sequential second-line endocrine therapies (ETs) in postmenopausal estrogen receptor-positive and HER2-negative metastatic breast cancer patients with lower sensitivity to initial ETs. Breast Cancer. 2020 May 11;: Authors: Iwamoto T, Fujisawa T, Shien T, Araki K, Sakamaki K, Sangai T, Kikawa Y, Takao S, Nishimura R, Takahashi M, Aihara T, Mukai H, Taira N Abstract PURPOSE: Second-line endocrine therapy (ET) for estrogen...
Wed May 13, 2020 13:16
Related ArticlesClinical applications of extracellular vesicle long RNAs. Crit Rev Clin Lab Sci. 2020 May 12;:1-14 Authors: Chen S, Zhu X, Huang S Abstract Extracellular vesicles (EVs), primarily exosomes and microvesicles, are critical intercellular mediators of communication. Over the past decade, improved knowledge and methodologies have enabled the detection and quantification of RNA species in EVs, despite their extremely low levels. Recently,...
Wed May 13, 2020 13:16
Related ArticlesUndertreatment of women with locoregionally advanced head and neck cancer. Cancer. 2019 09 01;125(17):3033-3039 Authors: Park A, Alabaster A, Shen H, Mell LK, Katzel JA Abstract BACKGROUND: It is difficult to predict whether a patient with head and neck cancer (HNC) is more likely to die of the cancer or another comorbidity. Competing event models can help to identify individual patients or groups of patients who may be undertreated...
Wed May 13, 2020 13:16
Related ArticlesEfficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study. Cancer Discov. 2019 03;9(3):370-383 Authors: Daver N, Garcia-Manero G, Basu S, Boddu PC, Alfayez M, Cortes JE, Konopleva M, Ravandi-Kashani F, Jabbour E, Kadia T, Nogueras-Gonzalez GM, Ning J, Pemmaraju N, DiNardo CD, Andreeff M, Pierce SA, Gordon T, Kornblau SM, Flores W, Alhamal Z, Bueso-Ramos...
Wed May 13, 2020 13:16
In HPV-negative oropharyngeal squamous cell carcinoma, elevated toll-like receptor 2 immunoexpression may increase the risk of disease-specific mortality. Oral Oncol. 2020 May 10;107:104778 Authors: Kylmä AK, Jouhi L, Mohamed H, Randén-Brady R, Mäkitie A, Atula T, Haglund C, Sorsa T, Hagström J Abstract OBJECTIVES: In oropharyngeal squamous cell carcinoma (OPSCC), toll-like receptors (TLR) 5 and 7 associate with the tumor's human papilloma virus (HPV)...
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Related ArticlesEffect of cervical manipulation on vertebral artery and cerebral haemodynamics in patients with chronic neck pain: a crossover randomised controlled trial. BMJ Open. 2019 05 28;9(5):e025219 Authors: Moser N, Mior S, Noseworthy M, Côté P, Wells G, Behr M, Triano J Abstract OBJECTIVE: It is hypothesised that cervical manipulation may increase the risk of cerebrovascular accidents. We aimed to determine whether cervical spine manipulation...
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Related ArticlesNonpharmacological Relaxation Technology for Office-Based Rhinologic Procedures. ORL J Otorhinolaryngol Relat Spec. 2019;81(1):48-54 Authors: Marino MJ, Luong A, Yao WC, Citardi MJ Abstract BACKGROUND: Office-based rhinologic procedures are increasingly performed to control costs and enhance patient convenience. Adequate management of pain and anxiety is essential for the technical performance of these procedures, in addition to ensuring...
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Related ArticlesAlkaline, protein, low-fat and low-acid diet in laryngopharyngeal reflux disease: Our experience on 65 patients. Clin Otolaryngol. 2019 05;44(3):379-384 Authors: Lechien JR, Huet K, Khalife M, De Marrez LG, Finck C, Harmegnies B, Saussez S PMID: 30548197 [PubMed - indexed for MEDLINE]
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Related ArticlesApproaching Otolaryngology Patients During the COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020 May 12;:194599820926144 Authors: Cui C, Yao Q, Zhang D, Zhao Y, Zhang K, Nisenbaum E, Cao P, Zhao K, Huang X, Leng D, Liu C, Li N, Luo Y, Chen B, Casiano R, Weed D, Sargi Z, Telischi F, Lu H, Denneny JC, Shu Y, Liu X Abstract Objective. To describe coronavirus disease 2019 (COVID-19) patient presentations requiring otolaryngology consultation...
Wed May 13, 2020 14:25
Related ArticlesImproved Tumor Control Related to Radiotherapy Technological Development for Hypopharyngeal Cancer. Laryngoscope. 2020 May 12;: Authors: Susko MS, Lazar AA, Dhar S, Chan JW, Shiao SL, Chapman CH, Johnson J, Quivey JM, Ryan WR, Heaton CM, Ha PK, Yom SS Abstract OBJECTIVES/HYPOTHESIS: Squamous cell carcinoma of the hypopharynx (SCCHP) is associated with worse survival compared to other head and neck subsites. This report quantifies the...
Wed May 13, 2020 14:25
Related ArticlesAzacitidine, as a DNMT inhibitor decreases hTERT gene expression and telomerase activity more effective compared with HDAC inhibitor in human Head and neck squamous cell carcinoma cell lines. Curr Mol Pharmacol. 2020 May 11;: Authors: Sepideh A, Nikoo N, Mahshid H Abstract BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is one of the most fatal malignancies worldwide and despite using various therapeutic strategies for the treatment...
Wed May 13, 2020 14:25
Related ArticlesAberrant methylation of WD-repeat protein 41 contributes to tumour progression in triple-negative breast cancer. J Cell Mol Med. 2020 May 12;: Authors: Wang H, Wu D, Cai L, Li X, Zhang Z, Chen S Abstract WD-repeat proteins are implicated in a variety of biological functions, most recently in oncogenesis. However, the underlying function of WD-repeat protein 41 (WDR41) in tumorigenesis remains elusive. The present study was aimed to explore...
Wed May 13, 2020 14:25
Related ArticlesDeep sequencing of circulating tumor DNA detects molecular residual disease and predicts recurrence in gastric cancer. Cell Death Dis. 2020 May 11;11(5):346 Authors: Yang J, Gong Y, Lam VK, Shi Y, Guan Y, Zhang Y, Ji L, Chen Y, Zhao Y, Qian F, Chen J, Li P, Zhang F, Wang J, Zhang X, Yang L, Kopetz S, Futreal PA, Zhang J, Yi X, Xia X, Yu P Abstract Identifying locoregional gastric cancer patients who are at high risk for relapse after...
Wed May 13, 2020 14:25
Utility of heavily T2-weighted MR myelography as the first step in CSF leak detection and the planning of epidural blood patches. J Clin Neurosci. 2020 May 08;: Authors: Kim BR, Lee JW, Lee E, Kang Y, Ahn JM, Kang HS Abstract Heavily T2-weighted MR myelography (HT2W-MRM) is emerging as an alternative approach for detection and follow up of CSF leaks. We aimed to assess epidural blood patch (EBP) treatment outcome when using HT2W-MRM as the primary modality...
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Role of Adjunct Treatments for Idiopathic CSF Leaks After Endoscopic Repair. Laryngoscope. 2020 May 13;: Authors: Sanghvi S, Sarna B, Alam E, Pasol J, Levine C, Casiano RR Abstract OBJECTIVE: A higher incidence of recurrent cerebrospinal fluid (CSF) leaks has been reported with idiopathic CSF leaks. A growing number of institutions advocate for routine use of intracranial pressure-lowering adjunct treatments after endoscopic repair. We report our results...
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Long-Term Outcomes from Blind Sac Closure of the External Auditory Canal: Our Institutional Experience in Different Pathologies. J Int Adv Otol. 2020 Apr;16(1):58-62 Authors: Kraus M, Hassannia F, J Bergin M, Al Zaabi K, Rutka JA Abstract OBJECTIVES: This study reports long-term results of blind sac closure of the external auditory canal performed for various pathologies, compares the complication rates and the need for revision surgery. MATERIALS...
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Related ArticlesSpinal Cord Stimulator Paddle Lead Surgery Complicated by Cerebrospinal Fluid Leak and Fistula Formation. Cureus. 2020 Apr 10;12(4):e7619 Authors: Hussain NS, Bissell JN, Gospodarev V, Hussain A Abstract Spinal cord stimulation (SCS) paddle leads placed via laminectomy procedures have become common as more data accumulates with regards to their clinical efficacy. In this paper, we describe a case of a 72-year-old male patient with failed...
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Related ArticlesPostoperative Thecal Sac Compression Induced by Hydrogel Dural Sealant after Spinal Schwannoma Removal. Korean J Neurotrauma. 2020 Apr;16(1):99-104 Authors: Han HJ, Jeong JH, Kim JW, Seung WB Abstract Cerebrospinal fluid (CSF) leak is a common complication of spinal and cranial surgery, and patients undergoing spinal tumor surgery are probably particularly predisposed due to the presence of an intradural tumor and many other factors....
Wed May 13, 2020 14:21
Related ArticlesLeaking the Diagnosis: A Case of Convulsive Status Epilepticus Due to Intracranial Hypotension. Neurocrit Care. 2019 12;31(3):562-566 Authors: Gilmour GS, Scott J, Couillard P Abstract BACKGROUND: We describe a case of convulsive status epilepticus caused by intracranial hypotension, a complication of spinal surgery. Intracranial hypotension (IH) is typically characterized by an orthostatic headache. There have been limited case reports...
Wed May 13, 2020 14:21
The Special Supplemental Nutrition Program for Women, Infants, and Children Spillover Effect: Do Siblings Reap the Benefits? J Acad Nutr Diet. 2020 May 10;: Authors: Steeves S, Acciai F, Tasevska N, DeWeese RS, Yedidia MJ, Ohri-Vachaspati P Abstract BACKGROUND: Participation in the Special Supplemental Nutrition Assistance Program for Women, Infants, and Children (WIC) among 0- to 5-year-old children is associated with healthier diets. Extension of dietary...
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Food Insecurity and Pediatric Malnutrition Related to Under- and Overweight in the United States: An Evidence Analysis Center Systematic Review. J Acad Nutr Diet. 2020 May 10;: Authors: Spoede E, Corkins MR, Spear BA, Becker PJ, Gunnell Bellini S, Hoy MK, Piemonte TA, Rozga M Abstract Both food insecurity and malnutrition are associated with adverse health outcomes in the pediatric population. However, the research on the relationship between these factors...
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A Paralyzing Case of Myalgias. Am J Case Rep. 2020 May 13;21:e922568 Authors: Simard C, Paquin A, Schwartz BC Abstract BACKGROUND Myalgia, which describes muscle pain or soreness, is a common presenting complaint encountered in the Emergency Department, in inpatient settings and in outpatient settings. Its differential diagnosis is broad and includes benign as well as more serious clinical entities. Some of the common causes of myalgias include viral...
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Related ArticlesA Rare Case of Systemic Mastocytosis with Associated Hematologic Neoplasm (SM-AHN) Involving Chronic Myeloid Leukemia: A Case Report and Literature Review. Am J Case Rep. 2020 May 13;21:e923354 Authors: Ibrahim FA, Abdulla MAJ, Soliman D, Al Sabbagh A, Nawaz Z, Akiki SJ, Shwaylia H, Yassin MA Abstract BACKGROUND Single or multiple cell line dysplasia is a characteristic feature of myelodysplastic syndrome. However, significant dysgranulopoiesis...
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Related ArticlesSpinal Cord Ischemia Because of Microvascular Thrombosis in a Patient with Necrotizing Pancreatitis. Case Report and Literature Review. Am J Case Rep. 2020 May 12;21:e923273 Authors: Dłuski OP, Durmaj AA, Kosieradzki M, Jonas M, Szczepankiewicz B, Czerwiński J, Adamczyk A, Palczewski P Abstract BACKGROUND Central nervous system ischemia in acute pancreatitis is rare with only a handful of cases reported in the literature. We report a...
Wed May 13, 2020 13:42
Related Articles[Audiological target parameters in clinical studies with implantable hearing systems]. HNO. 2020 May 12;: Authors: Maier H Abstract A multitude of new implantable hearing systems and applications creates new options for pathologies which have been difficult to treat in the past. For many of these hearing systems preclinical technical methods to characterize devices and applications are limited. Therefore, clearly structured clinical...
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Related Articles[Exosomes as immune regulators in head and neck cancer]. HNO. 2020 May 12;: Authors: Ludwig S, Rotter N, Theodoraki MN, Jablonska J, Lammert A, Lang S Abstract Exosomes, virus-sized nanovesicles, are utilized as messenger systems of our body to communicate with other body cells and regulate immune functions. Almost all cells produce exosomes and are able to interact with immune cells in the blood stream and peripheral body areas....
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Related Articles[Gunshot wound of the paranasal sinuses with an unusual route of the bullet]. HNO. 2020 May 11;: Authors: Banisch T, Heide S, Kaden I, Herzog M, Weigert N, Plontke SK PMID: 32394148 [PubMed - as supplied by publisher]
Wed May 13, 2020 13:43
Abstract Previous studies showed that probiotics supplementation contributed to alleviate obesity. This work was to assess the efficacy of Lactobacillus plantarum FRT10 from sour dough in alleviating obesity in mice fed with a high-fat diet (HFD), and the underlying mechanisms focusing on modulation of the gut microbiota profile. Kunming mice were fed with a regular diet (CT), a high-fat diet (HFD), and two HFDs containing low and high doses of L. plantarum FRT10 for 8 weeks....
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Abstract The effective removal of dags (manure balls) from cattle, sheep and goats is a significant issue for the livestock industry. Dags are hard recalcitrant deposits composed of materials, such as faeces, hair, soil, urine, feed and straw, and attach to the animal through the hair rather than the skin. Dags build up during wet periods, especially on long haired breeds, and can weigh up to 40 kg per animal for cattle. Dag removal prior to slaughter...
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Abstract Formulated conidia of insect-pathogenic fungi, such as Beauveria and Metarhizium, serve as the active ingredients of fungal insecticides but are highly sensitive to persistent high temperatures (32–35 °C) that can be beyond their upper thermal limits especially in tropical areas and during summer months. Fungal heat tolerance and inter- or intra-specific variability are critical factors and limitations to field applications of fungal pesticides...
Wed May 13, 2020 03:00
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