Antibiotics, Vol. 9, Pages 253: Self-Reported Antimicrobial Stewardship Practices in Primary Care Using the TARGET Antibiotics Self-Assessment Tool Antibiotics doi: 10.3390/antibiotics9050253 Authors: Jones Verlander Lecky Altaf Pilat McNulty The self-assessment tool (SAT) is a 16-question self-report of antimicrobial stewardship practices in primary care, available in the TARGET (Treat Antibiotics Responsibly, Guidance Education and Tools) Antibiotics Toolkit. This...
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Antibiotics, Vol. 9, Pages 252: Mersaquinone, A New Tetracene Derivative from the Marine-Derived Streptomyces sp. EG1 Exhibiting Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) Antibiotics doi: 10.3390/antibiotics9050252 Authors: Min Cheol Kim Reiko Cullum Ali M. S. Hebishy Hala A. Mohamed Ahmed H. I. Faraag Nehad M. Salah Mohamed S. Abdelfattah William Fenical New antibiotics are desperately needed to overcome the societal challenges being encountered...
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Antioxidants, Vol. 9, Pages 423: Brain Transcriptome Analysis Links Deficiencies of Stress-Responsive Proteins to the Pathomechanism of Kii ALS/PDC Antioxidants doi: 10.3390/antiox9050423 Authors: Morimoto Ishikawa Watanabe Isoda Takao Nakamura Ozawa Hirokawa Kuzuhara Okano Kokubo Amyotrophic lateral sclerosis and Parkinsonism-dementia complex (ALS/PDC) is a unique endemic neurodegenerative disease, with high-incidence foci in Kii Peninsula, Japan....
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Atmosphere, Vol. 11, Pages 505: Estimations of the Mexicali Valley (Mexico) Mixing Height Atmosphere doi: 10.3390/atmos11050505 Authors: Salcido Celada-Murillo Carreón-Sierra Castro Peralta Salcido-González Hernández-Flores Tamayo-Flores Martínez-Flores We report estimations of the Mexicali Valley (Mexico) mixing height for three seasons. Surface and upper air meteorological measurements were carried out nearby Cerro Prieto geothermal power plant during...
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Atmosphere, Vol. 11, Pages 504: Performance of Two Different Techniques to Concentrate Samples for Bioaerosol Quantification Atmosphere doi: 10.3390/atmos11050504 Authors: Oh Han Mainelis We evaluated two concentrating techniques that could be used to improve bioaerosol detection and quantification: A BioChromato Smart Evaporator C1 (BioChromato, Inc.) and two Concentrating Pipette (CP) models (CP-150 and CP-Select) (InnovaPrep, LLC). We determined the concentration factor (CF)...
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Atmosphere, Vol. 11, Pages 503: The Change Characteristics and Interactions of Soil Moisture and Temperature in the Farmland in Wuchuan County, Inner Mongolia, China Atmosphere doi: 10.3390/atmos11050503 Authors: Ziyuan Zhang Zhihua Pan Feifei Pan Jun Zhang Guolin Han Na Huang Jialin Wang Yuying Pan Zizhong Wang Ruiqi Peng Soil moisture and temperature are both significant factors for crop growth and development. They are also the main influencing factors of...
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Biomolecules, Vol. 10, Pages 765: Near-Surface Studies of the Changes to the Structure and Mechanical Properties of Human Enamel under the Action of Fluoride Varnish Containing CPP–ACP Compound Biomolecules doi: 10.3390/biom10050765 Authors: Izabela Świetlicka Damian Kuc Michał Świetlicki Marta Arczewska Siemowit Muszyński Ewa Tomaszewska Adam Prószyński Krzysztof Gołacki Jerzy Błaszczak Krystian Cieślak Daniel Kamiński Maria Mielnik-Błaszczak Changes...
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Biomolecules, Vol. 10, Pages 766: Acute Effects of Butyrate on Induced Hyperpermeability and Tight Junction Protein Expression in Human Colonic Tissues Biomolecules doi: 10.3390/biom10050766 Authors: Tabat Marques Markgren Löfvendahl Brummer Wall Intact intestinal barrier function is essential for maintaining intestinal homeostasis. A dysfunctional intestinal barrier can lead to local and systemic inflammation through translocation of luminal antigens and has been...
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Biomolecules, Vol. 10, Pages 764: Site-Specific Antibody–Drug Conjugates in Triple Variable Domain Fab Format Biomolecules doi: 10.3390/biom10050764 Authors: Dobeen Hwang Christoph Rader The interest in replacing the conventional immunoglobulin G (IgG) format of monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) with alternative antibody and antibody-like scaffolds reflects a need to expand their therapeutic utility and potency while retaining their exquisite...
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Brain Sciences, Vol. 10, Pages 291: Self-Reported Autistic Traits Using the AQ: A Comparison between Individuals with ASD, Psychosis, and Non-Clinical Controls Brain Sciences doi: 10.3390/brainsci10050291 Authors: Laura Fusar-Poli Alessia Ciancio Alberto Gabbiadini Valeria Meo Federica Patania Alessandro Rodolico Giulia Saitta Lucia Vozza Antonino Petralia Maria Salvina Signorelli Eugenio Aguglia The term “autism” was originally coined...
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Brain Sciences, Vol. 10, Pages 292: Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype/Presentation: Research Progress and Translational Studies Brain Sciences doi: 10.3390/brainsci10050292 Authors: Ike C. de la Peña Michael C. Pan Chau Giang Thai Tamara Alisso Research on the predominantly inattentive attention-deficit/hyperactivity disorder (ADHD-PI) subtype/presentation is important given its high prevalence, but paradoxically it is under-recognized...
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Cancers, Vol. 12, Pages 1236: MicroRNA Response and Toxicity of Potential Pathways in Human Colon Cancer Cells Exposed to Titanium Dioxide Nanoparticles Cancers doi: 10.3390/cancers12051236 Authors: Li Jia Deng Wang Zuberi Yang Ba Chen Titanium dioxide nanoparticles (TiO2-NPs) are widely used for biomedical and food applications, the toxicity of TiO2-NPs in vivo and in vitro has been elucidated, but the underlying cytotoxicity of TiO2-NPs against microRNA...
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Cancers, Vol. 12, Pages 1235: A Preoperative Clinical Risk Score Including C-Reactive Protein Predicts Histological Tumor Characteristics and Patient Survival after Surgery for Sporadic Non-Functional Pancreatic Neuroendocrine Neoplasms: An International Multicenter Cohort Study Cancers doi: 10.3390/cancers12051235 Authors: Florian Primavesi Valentina Andreasi Frederik J.H. Hoogwater Stefano Partelli Dominik Wiese Charlotte Heidsma Benno Cardini Eckhard Klieser Katharina...
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Cancers, Vol. 12, Pages 1237: Biliary Tract Cancer: Current Medical Treatment Strategies Cancers doi: 10.3390/cancers12051237 Authors: Ester Oneda Mohammed Abu Hilal Alberto Zaniboni Background: Biliary tract cancers (BTCs) include cholangiocarcinomas and gallbladder cancers usually present at an advanced stage, which are considered resectable in less than 20% of cases and characterised by poor prognosis. Methods: In this review, we discussed the most recent therapeutic options...
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Cancers, Vol. 12, Pages 1234: Predictive Value of Early Post-Treatment Diffusion-Weighted MRI for Recurrence or Tumor Progression of Head and Neck Squamous Cell Carcinoma Treated with Chemo-Radiotherapy Cancers doi: 10.3390/cancers12051234 Authors: Esteban Brenet Coralie Barbe Christine Hoeffel Xavier Dubernard Jean-Claude Merol Léa Fath Stéphanie Servagi-Vernat Marc Labrousse Aims: To investigate the predictive capacity of early post-treatment diffusion-weighted...
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Cancers, Vol. 12, Pages 1231: Chemoresistance-Associated Silencing of miR-4454 Promotes Colorectal Cancer Aggression through the GNL3L and NF-κB Pathway Cancers doi: 10.3390/cancers12051231 Authors: Thetchinamoorthy Kannathasan Wei-Wen Kuo Ming-Cheng Chen Vijaya Padma Viswanadha Chia-Yao Shen Chuan-Chou Tu Yu-Lan Yeh Mahalakshmi Bharath Marthandam Asokan Shibu Chih-Yang Huang Guanine nucleotide-binding protein-like-3-like (GNL3L) is a crucial regulator of NF-κB...
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Cancers, Vol. 12, Pages 1232: Communication in the Cancer Microenvironment as a Target for Therapeutic Interventions Cancers doi: 10.3390/cancers12051232 Authors: Dominiak Chełstowska Olejarz Nowicka The tumor microenvironment (TME) is a complex system composed of multiple cells, such as non-cancerous fibroblasts, adipocytes, immune and vascular cells, as well as signal molecules and mediators. Tumor cells recruit and reprogram other cells to produce factors that maintain...
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Cancers, Vol. 12, Pages 1221: Immune Cytolytic Activity for Comprehensive Understanding of Immune Landscape in Hepatocellular Carcinoma Cancers doi: 10.3390/cancers12051221 Authors: Hideo Takahashi Tsutomu Kawaguchi Li Yan Xuan Peng Qianya Qi Luc G.T. Morris Timothy A. Chan Allan Tsung Eigo Otsuji Kazuaki Takabe Cytolytic activity score (CYT), defined by granzyme A and perforin expression, is a useful marker for underlying immunity. We hypothesized that CYT-high...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1222: Comparison of Circulating Cell-Free DNA Extraction Methods for Downstream Analysis in Cancer Patients Cancers doi: 10.3390/cancers12051222 Authors: Paul van der Leest Pieter A. Boonstra Arja ter Elst Léon C. van Kempen Marco Tibbesma Jill Koopmans Anneke Miedema Menno Tamminga Harry J. M. Groen Anna K. L. Reyners Ed Schuuring Circulating cell-free DNA (ccfDNA) may contain DNA originating from the tumor in plasma of cancer patients...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1220: Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated with African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations Cancers doi: 10.3390/cancers12051220 Authors: Melissa Davis Rachel Martini Lisa Newman Olivier Elemento Jason White Akanksha Verma Indrani Datta Indra Adrianto Yalei Chen Kevin Gardner Hyung-Gyoon Kim Windy D. Colomb Isam-Eldin...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1218: Past, Present and Future of Epigenetics in Adrenocortical Carcinoma Cancers doi: 10.3390/cancers12051218 Authors: Madeleine Ettaieb Thomas Kerkhofs Manon van Engeland Harm Haak DNA methylation profiling has been suggested a reliable technique to distinguish between benign and malignant adrenocortical tumors, a process which with current diagnostic methods remains challenging and lacks diagnostic accuracy of borderline tumors. Accurate distinction...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1217: Immune Cell Subtypes and Cytokines in Lung Tumor Microenvironment: Influence of COPD Cancers doi: 10.3390/cancers12051217 Authors: Jun Tang Daniel Ramis-Cabrer Víctor Curull Xuejie Wang Liyun Qin Mercé Mateu-Jiménez Xavier Duran Lara Pijuan Alberto Rodríguez-Fuster Rafael Aguiló Espases Esther Barreiro Background: The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1216: GRK2-Dependent HuR Phosphorylation Regulates HIF1α Activation under Hypoxia or Adrenergic Stress Cancers doi: 10.3390/cancers12051216 Authors: Clara Reglero Vanesa Lafarga Verónica Rivas Ángela Albitre Paula Ramos Susana R. Berciano Olga Tapia María L. Martínez-Chantar Federico Mayor Jr Petronila Penela Adaptation to hypoxia is a common feature in solid tumors orchestrated by oxygen-dependent and independent upregulation of the...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1215: Optimization and Characterization of Protein Nanoparticles for the Targeted and Smart Delivery of Cytochrome c to Non-Small Cell Lung Carcinoma Cancers doi: 10.3390/cancers12051215 Authors: Vanessa Barcelo-Bovea Irivette Dominguez-Martinez Freisa Joaquin-Ovalle Luis A. Amador Elizabeth Castro-Rivera Kristofer Medina-Álvarez Anthony McGoron Kai Griebenow Yancy Ferrer-Acosta The delivery of Cytochrome c (Cyt c) to the cytosol stimulates...
Wed May 13, 2020 03:00
Cancers, Vol. 12, Pages 1214: Molecular-Biology-Driven Treatment for Metastatic Colorectal Cancer Cancers doi: 10.3390/cancers12051214 Authors: Eleonora Lai Nicole Liscia Clelia Donisi Stefano Mariani Simona Tolu Andrea Pretta Mara Persano Giovanna Pinna Francesca Balconi Annagrazia Pireddu Valentino Impera Marco Dubois Marco Migliari Dario Spanu Giorgio Saba Silvia Camera Francesca Musio Pina Ziranu Marco Puzzoni Laura Demurtas Valeria...
Wed May 13, 2020 03:00
Cells, Vol. 9, Pages 1219: The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation Cells doi: 10.3390/cells9051219 Authors: Yang Zhou Zhizi Tong Songhong Jiang Wenyan Zheng Jianjun Zhao Xiangmei Zhou The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and activates caspase-1, which provokes...
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Cells, Vol. 9, Pages 1220: Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking Cells doi: 10.3390/cells9051220 Authors: Urata Saiki Tsukamoto Sago Hibi Okajima Takeuchi Biochemical and genetic studies have indicated that O-linked glycosylation such as O-glucose (Glc), fucose (Fuc), and N-acetylglucosamine (GlcNAc) is critical for Notch signaling; however, it is not fully understood how...
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Cells, Vol. 9, Pages 1216: Isoprenylcysteine Carboxyl Methyltransferase and Its Substrate Ras Are Critical Players Regulating TLR-Mediated Inflammatory Responses Cells doi: 10.3390/cells9051216 Authors: Woo Seok Yang Han Gyung Kim Eunji Kim Sang Yun Han Nur Aziz Young-Su Yi Sunggyu Kim Yunmi Lee Byong Chul Yoo Jeung-Whan Han Narayanan Parameswaran Ji Hye Kim Jae Youl Cho In this study, we investigated the functional role of isoprenylcysteine carboxyl...
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Cells, Vol. 9, Pages 1215: Alzheimer’s Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α Cells doi: 10.3390/cells9051215 Authors: Sáez-Orellana Octave Pierrot Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. Mutations in genes encoding proteins involved in amyloid-β peptide (Aβ) production are responsible for inherited AD cases. The amyloid cascade hypothesis was proposed to explain the pathogeny....
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Cells, Vol. 9, Pages 1214: LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction Cells doi: 10.3390/cells9051214 Authors: Qiong Fan Rikke Christine Nørgaard Ivar Grytten Cecilie Maria Ness Christin Lucas Kristin Vekterud Helen Soedling Jason Matthews Roza Berhanu Lemma Odd Stokke Gabrielsen Christian Bindesbøll Stine Marie Ulven Hilde Irene Nebb Line Mariann Grønning-Wang Thomas Sæther...
Wed May 13, 2020 03:00
Cells, Vol. 9, Pages 1213: Putting the Brakes on Tumorigenesis with Natural Products of Plant Origin: Insights into the Molecular Mechanisms of Actions and Immune Targets for Bladder Cancer Treatment Cells doi: 10.3390/cells9051213 Authors: Qiushuang Wu Janet P. C. Wong Hang Fai Kwok Bladder cancer is the 10th most commonly diagnosed cancer worldwide. Although the incidence in men is 4 times higher than that in women, the diagnoses are worse for women. Over the past 30 years, the...
Wed May 13, 2020 03:00
Cells, Vol. 9, Pages 1211: Characterization of Plasma-Derived Small Extracellular Vesicles Indicates Ongoing Endothelial and Platelet Activation in Patients with Thrombotic Antiphospholipid Syndrome Cells doi: 10.3390/cells9051211 Authors: Ula Štok Elizabeta Blokar Metka Lenassi Marija Holcar Mojca Frank-Bertoncelj Andreja Erman Nataša Resnik Snežna Sodin-Šemrl Saša Čučnik Katja Perdan Pirkmajer Aleš Ambrožič Polona Žigon Antiphospholipid syndrome (APS)...
Wed May 13, 2020 03:00
Cells, Vol. 9, Pages 1212: Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases Cells doi: 10.3390/cells9051212 Authors: Eline Geervliet Ruchi Bansal Chronic liver diseases, characterized by an excessive accumulation of extracellular matrix (ECM) resulting in scar tissue formation, are a growing health problem causing increasing morbidity and mortality worldwide. Currently, therapeutic options for tissue fibrosis are severely limited, and organ...
Wed May 13, 2020 03:00
Cells, Vol. 9, Pages 1209: P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b Cells doi: 10.3390/cells9051209 Authors: Randa Naffa Lisa Vogel Luca Hegedűs Katalin Pászty Sarolta Tóth Kornélia Kelemen Neha Singh Attila Reményi Enikő Kállay Mihály Cserepes József Tóvári Michael Grusch Ágnes Enyedi Metastatic melanoma is the most aggressive type of skin cancer. Previously, we identified...
Wed May 13, 2020 03:00
Cells, Vol. 9, Pages 1210: Drug Repurposing and DNA Damage in Cancer Treatment: Facts and Misconceptions Cells doi: 10.3390/cells9051210 Authors: Eleni Sertedaki Athanassios Kotsinas Drug repurposing appears to offer an attractive alternative in finding new anticancer agents. Their applicability seems to have multiple benefits, among which are the potential of immediate efficacy assessment in clinical trials and the existence of patient safety and tolerability evidence. Nevertheless,...
Wed May 13, 2020 03:00
Cells, Vol. 9, Pages 1208: Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2 Protein in the Kidney Collecting Duct Cells doi: 10.3390/cells9051208 Authors: Hyo-Jung Choi Hyo-Ju Jang Euijung Park Stine Julie Tingskov Rikke Nørregaard Hyun Jun Jung Tae-Hwan Kwon Sorting nexin 27 (SNX27), a PDZ (Postsynaptic density-95/Discs large/Zonula occludens 1) domain-containing protein, cooperates with a retromer complex, which regulates intracellular trafficking...
Wed May 13, 2020 03:00
Cells, Vol. 9, Pages 1207: Electrospun PLGA Fiber Diameter and Alignment of Tendon Biomimetic Fleece Potentiate Tenogenic Differentiation and Immunomodulatory Function of Amniotic Epithelial Stem Cells Cells doi: 10.3390/cells9051207 Authors: Mohammad El El Khatib Annunziata Mauro Miriam Di Di Mattia Ralf Wyrwa Martina Schweder Massimo Ancora Francesco Lazzaro Paolo Berardinelli Luca Valbonetti Oriana Di Di Giacinto Andrea Polci Cesare Cammà Matthias Schnabelrauch...
Wed May 13, 2020 03:00
Cells, Vol. 9, Pages 1206: The Role of Human γδ T Cells in Anti-Tumor Immunity and Their Potential for Cancer Immunotherapy Cells doi: 10.3390/cells9051206 Authors: Yuxia Liu Cai Zhang γδ T cells are a distinct subset of T cells whose T cell receptors consist of γ chains and δ chains, different from conventional αβ T cells. γδ T cells are considered as a member of the innate immunity because of their non-MHC...
Wed May 13, 2020 03:00
Cells, Vol. 9, Pages 1205: UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway Cells doi: 10.3390/cells9051205 Authors: Tianhong Chen Wenjuan Zhang Bo Huang Xuan Chen Cao Huang Mutations of Ubiquilin 2 (UBQLN2) or TANK-binding kinase 1 (TBK1) are associated with amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD). However, the mechanisms whereby UBQLN2 or TBK1 mutations lead to ALS and FTD remain unclear. Here, we explored the...
Wed May 13, 2020 03:00
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