Multiple eruptive myxoid dermatofibroma in a man with chronic hepatitis B infection

We report the first known case of multiple eruptive myxoid dermatofibromas (MEMDF) in a male with chronic hepatitis B infection presenting with eruptive lesions showing marked deposits of dermal mucin. Tumor cells were positive for CD68 and vimentin and negative for S-100 and SMA. CD34 stained regular endothelial cells. Work-up showed asymptomatic chronic hepatitis B infection without cirrhosis. This case highlights an extremely rare histologic variant and the importance of screening for altered immunity in patients with eruptive dermatofibromas.