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Τρίτη 5 Δεκεμβρίου 2017

Noninvasive electrical conductivity measurement by MRI: a test of its validity and the electrical conductivity characteristics of glioma

Abstract

Objectives

This study noninvasively examined the electrical conductivity (σ) characteristics of diffuse gliomas using MRI and tested its validity.

Methods

MRI including a 3D steady-state free precession (3D SSFP) sequence was performed on 30 glioma patients. The σ maps were reconstructed from the phase images of the 3D SSFP sequence. The σ histogram metrics were extracted and compared among the contrast-enhanced (CET) and noncontrast-enhanced tumour components (NCET) and normal brain parenchyma (NP). Difference in tumour σ histogram metrics among tumour grades and correlation of σ metrics with tumour grades were tested. Validity of σ measurement using this technique was tested by correlating the mean tumour σ values measured using MRI with those measured ex vivo using a dielectric probe.

Results

Several σ histogram metrics of CET and NCET of diffuse gliomas were significantly higher than NP (Bonferroni-corrected p ≤ .045). The maximum σ of NCET showed a moderate positive correlation with tumour grade (r = .571, Bonferroni-corrected p = .018). The mean tumour σ measured using MRI showed a moderate positive correlation with the σ measured ex vivo (r = .518, p = .040).

Conclusions

Tissue σ can be evaluated using MRI, incorporation of which may better characterise diffuse gliomas.

Key Points

This study tested the validity of noninvasive electrical conductivity measurements by MRI.

This study also evaluated the electrical conductivity characteristics of diffuse glioma.

Gliomas have higher electrical conductivity values than the normal brain parenchyma.

Noninvasive electrical conductivity measurement can be helpful for better characterisation of glioma.



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