Contiguous verrucous proliferations in syringocystadenoma papilliferum: a retrospective analysis with additional evaluation via mutation-specific BRAF V600E immunohistochemistry

Abstract

Syringocystadenoma papilliferum (SCAP) is a benign adnexal neoplasm with apocrine differentiation.^1,2 which may be derived from pluripotent cells.³ The lesion may develop within a pre-existing nevus sebaceus, but the majority of cases arise sporadically.³ Congenital lesions in a Blaschkoid distribution have also been reported, and these cases are thought to represent genetic mosaicism.^4,5,6 The tumor has a varied clinical appearance, but typically presents as a raised warty, hairless plaque or nodule.³