Analysis of sulfated glycosaminoglycan composition change in intrinsically aged and photoaged human skin using an enzymatic degradation method

Glycosaminoglycans (GAGs) are long and linear polysaccharides composed of repeating specific disaccharide units, and 6 different GAGs are known: chondroitin sulfate (CS), dermatan sulfate (DS), heparan sulfate (HS), heparin (HP), keratan sulfate (KS), and hyaluronic acid (HA) [1]. GAGs exist as alone (HA) or proteoglycan-attached forms (others) in extracellular matrix and cell surface throughout the body, and participate in diverse structural and physiological functions [1].