Lymphocytes in Sweet Syndrome: A Potential Diagnostic Pitfall

Abstract

Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a distinct clinical-pathologic entity characterized by an abrupt eruption of tender or painful erythematous or violaceous plaques or nodules, with histopathologic features of a predominantly neutrophilic infiltrate in the dermis without leukocytoclastic vasculitis, constituting the major criteria for the diagnosis (1, 2). Clinically, these present as acutely eruptive juicy, erythematous papules and plaques. SS may be associated with a variety of systemic disorders, including malignancy, medications, and pregnancy.