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Πέμπτη 12 Οκτωβρίου 2017


06:29
Platinum or nonplatinum in recurrent ovarian cancer: that is the question
Future Oncology, Ahead of Print. http://ift.tt/2ygUoYY
 Oncology

06:29
Trabectedin mechanism of action and platinum resistance: molecular rationale
Future Oncology, Ahead of Print. http://ift.tt/2wRak2B
 Oncology

06:29
When nonplatinum is the answer: the role of trabectedin plus pegylated liposomal doxorubicin in recurrent ovarian cancer
Future Oncology, Ahead of Print. http://ift.tt/2ygUnnS
 Oncology
06:29
Managing relapsed ovarian cancer in a rapidly evolving landscape
Future Oncology, Ahead of Print. http://ift.tt/2wRFHKn
 Oncology

06:29
Update on relapsed ovarian cancer treatment: from new consensus to daily clinical practice
Future Oncology, Ahead of Print. http://ift.tt/2ygUjo8
 Oncology

06:23
Stereoselective Catalytic Synthesis of Alkynylated Phosphaethenes Leading to the Activation-Free Gold Catalysis
The π-accepting property of alkene-like phosphaethenes (-P=C<) has been attractive to develop...
 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
06:23
The effect of using a dielectric matching medium in focused microwave radiometry: an anatomically detailed head model study
Abstract Microwave radiometry is a passive technique used to measure in-depth...
 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao

06:23
Atmospheric deposition of inorganic nitrogen in a semi-arid grassland of Inner Mongolia, China
Abstract Due to increasing global demand for crop production and energy use, more and more reactive nitrogen (Nr) has been generated and emitted to the environment. As a result, global atmospheric nitrogen (N) deposition has tripled since the industrial revolution and the ecological environment and...
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

06:13
Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimers disease [Research]
Interactions of the presynaptic proteins, neuronal pentraxin 2 (NPTX2) and neurexin 2α (NRXN2α), with their respective postsynaptic functional partners, GluA4-containing glutamate (AMPA4) receptor and neuroligin 1 (NLGN1), enhance excitatory synaptic activity in some areas of the hippocampus and cerebral...
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
06:13
A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis [Molecular Bases of Disease]
Fibrosis can disrupt tissue structure and integrity and impair organ function. Fibrosis is characterized by abnormal collagen accumulation in the extracellular matrix. Pharmacological inhibition of collagen secretion therefore represents a promising strategy for the management of fibrotic disorders,...
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

06:13
Mevalonate 5-diphosphate mediates ATP binding to the mevalonate diphosphate decarboxylase from the bacterial pathogen Enterococcus faecalis [Enzymology]
The mevalonate pathway produces isopentenyl diphosphate (IPP), a building block for polyisoprenoid synthesis, and is a crucial pathway for growth of the human bacterial pathogen Enterococcus faecalis. The final enzyme in this pathway, mevalonate diphosphate decarboxylase (MDD), acts on mevalonate diphosphate...
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

06:09
Interview about the GIFT Trial, Pharmacogenetics, and Warfarin
Pharmacogenomics, Ahead of Print. http://ift.tt/2kJK7S6
 Medicine by Alexandros G.Sfakianakis
06:03
Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase
Altered sphingolipid metabolism is associated with increased inflammation; however, the impact of inflammatory mediators, including neutrophil elastase (NE), on airway sphingolipid homeostasis remains unknown. Using a well-characterized mouse model of NE oropharyngeal aspiration, we investigated a potential...
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

06:03
Ion channels of the lung and their role in disease pathogenesis
Maintenance of normal epithelial ion and water transport in the lungs includes providing a thin layer of surface liquid that coats the conducting airways. This airway surface liquid is critical for normal lung function in a number of ways, but perhaps most importantly, is required for normal mucociliary...
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

06:03
Toll-like receptor 2 and 4 have Opposing Roles in the Pathogenesis of Cigarette Smoke-induced Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of morbidity and death and imposes major socioeconomic burdens globally. It is a progressive and disabling condition that severely impairs breathing and lung function. There is a lack of effective treatments for COPD, which is a...
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
05:59
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding
 Oncology

05:58
Low-intensity LED therapy ( λ 640 ± 20 nm) on saphenectomy healing in patients who underwent coronary artery bypass graft: a randomized, double-blind study
Abstract Myocardial revascularization surgery (CABG) is the most appropriate treatment for coronary artery disease. Currently, the great challenge is to reduce postoperative complications, such as wound infections, dehiscence, pain, and patients' quality of life. The saphenectomy is the target of complications...
 Medicine by Sfakianakis G. Alexandros

05:58
Analysis of choroidal thickness in ocular hypertensive patients using enhanced depth imaging optical coherence tomography
Abstract This study aimed to compare choroidal thickness between subjects with ocular hypertension (OHT) and normal individuals and explore factors affecting choroidal thickness. This study included 60 untreated newly diagnosed OHT eyes and 60 normal eyes. Choroidal thickness obtained from Cirrus HD-OCT...
 Medicine by Sfakianakis G. Alexandros
05:55
Cutting the Holy Dome: The Evolution of Vertical Alar Resection
Abstract Introduction Dome division or vertical dome division (VDD) is a tip plasty technique that is effective when applied appropriately to suitable patients. For 15 years, we have used VDD and made modifications as needed. In classical VDD, the dome area is cut and left to heal, but experience shows...
 Medicine by Sfakianakis G. Alexandros

05:48
J & B Sausage Company, Inc. Recalls Fully Cooked Shredded Beef Products Due To Possible Foreign Matter Contamination
J & B Sausage Company, Inc., doing business as J Bar B Foods, a Waelder, Texas establishment, is recalling approximately 12,816 pounds of fully cooked shredded beef products that may be contaminated with extraneous materials, specifically plastic. from Medicine via paythelady.61 on Inoreader http://ift.tt/2hEoygT
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182,alsfakia@gmail.com

05:46
Publisher's Note: Rho differentially regulates the Hippo pathway by modulating the interaction between Amot and Nf2 in the blastocyst. Development doi: 10.1242/dev.157917 [PUBLISHER'S NOTE]
Xianle Shi, Zixi Yin, Bin Ling, Lingling Wang, Chang Liu, Xianhui Ruan, Weiyu Zhang, and Lingyi Chen from A1 via xlomafota.13 on Inoreader http://ift.tt/2zlUbE2 via IFTTT
 Medicine Sfakianakis G. Alexandros
05:43
The Impact of Religiosity on Substance Abuse and Obesity in African Americans
Abstract Among the African American community, there exist many health disparities which warrant greater examination through the practice of social work. The aim of the present research was to explore the impact of religiosity on substance abuse and obesity among African American populations by employing...
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

05:38
UPDATE: Greencore USA, LLC Recalls Egg Salad Sandwiches, Ham Salad Sandwiches, and Seafood Stuffing Because of Possible Health Risk
Greencore, USA, LLC is voluntarily recalling egg salad sandwiches, ham salad sandwiches, and seafood stuffing as listed below. The products are being recalled because Listeria monocytogenes was found in environmental sampling conducted by FDA. from Medicine via paythelady.61 on Inoreader http://ift.tt/2z45O1d
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182,alsfakia@gmail.com

05:36
Rescue of Outer Hair Cells with Antisense Oligonucleotides in Usher Mice Is Dependent on Age of Treatment
AbstractThe absence of functional outer hair cells is a component of several forms of hereditary hearing impairment, including Usher syndrome, the most common cause of concurrent hearing and vision loss. Antisense oligonucleotide (ASO) treatment of mice with the human Usher mutation,Ush1c c.216G>A,...
 OtoRhinoLaryngology by Alexandros G.Sfakianakis
05:30
Baker’s Cyst – Everything You Need To Know – Dr. Nabil Ebraheim
 Cancerology Oncology

05:30
Monocytes and granulocytes reduce CD38 expression levels on myeloma cells in patients treated with daratumumab
Purpose: Daratumumab treatment results in a marked reduction of CD38 expression on multiple myeloma (MM) cells. The aim of this study was to investigate the clinical implications and the underlying mechanisms of daratumumab-mediated CD38 reduction. Experimental design: We evaluated the effect of daratumumab...
 Oncology

05:30
CAR T therapy targeting ICAM-1 eliminates advanced human thyroid tumors
Purpose: Poorly-differentiated thyroid cancer and anaplastic thyroid cancer (ATC) are rare yet lethal malignancies with limited treatment options. Many malignant tumors including papillary thyroid cancer (PTC) and ATC are associated with increased expression of ICAM-1, providing a rationale for utilizing...
 Oncology
05:20
Effects of age and exercise training on coronary microvascular smooth muscle phenotype and function
Coronary microvascular function and blood flow responses during acute exercise are impaired in the aged heart, but can be restored by exercise training. Coronary microvascular resistance is directly dependent on vascular smooth muscle function in coronary resistance arterioles; therefore, we hypothesized...
 Cancerology Oncology

05:20
Translation in Progress: Hypoxia 2017
N/A from # & – All via ola Kala on Inoreader http://ift.tt/2gAaNQI
 Cancerology Oncology

05:20
A novel single-beat approach to assess right ventricular systolic function
Clinical assessment of right ventricular (RV) contractility in diseases such as pulmonary arterial hypertension (PAH) has been hindered by the lack of a robust methodology. Here, a novel clinically-viable single-beat method was developed to assess end-systolic elastance (Ees), a measure of RV contractility....
 Cancerology Oncology
05:20
Multiple coupled resonances in the human vascular tree – refining the Westerhof model of the arterial system
The human arterial vascular tree can be described by multi-compartment models using electrical components. Being first introduced in the 1960s by Noordergraaf and Westerhof these hardware-based approaches required several simplifications. We were able to remove the restrictions using modern software...
 Cancerology Oncology

05:20
Aging is associated with Increased Propensity for Central Apnea during NREM Sleep
The reason for increased sleep disordered breathing with predominance of central apneas in the elderly is unknown. We hypothesized that the propensity to central apneas is increased in older adults, manifested by a reduced carbon-dioxide (CO2) reserve in older compared to young adults during non-REM...
 Cancerology Oncology

05:20
Imaging in metabolic research: challenges and opportunities
N/A from # & – All via ola Kala on Inoreader http://ift.tt/2i6tsan
 Cancerology Oncology
05:14
Multiple coupled resonances in the human vascular tree - refining the Westerhof model of the arterial system
The human arterial vascular tree can be described by multi-compartment models using electrical components. Being first introduced in the 1960s by Noordergraaf and Westerhof these hardware-based approaches required several simplifications. We were able to remove the restrictions using modern software...
 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026

05:08
Today, 12 October, is Stem Cell Awareness Day and in…
 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182,alsfakia@gmail.com

05:07
Therapeutic hypothermia in acute traumatic spinal cord injury
Therapeutic hypothermia is already widely acknowledged as an effective neuroprotective intervention, especially within the acute care setting in relation to conditions such as cardiac arrest and neonatal encephalopathy. Its multifactorial mechanisms of action, including lowering metabolic rate and reducing...
 OTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174
05:07
Phosphate replacement in the critically ill: potential implications for military patients
Background Severe hypophosphataemia in the intensive care unit (ICU) setting has been widely associated with adverse clinical outcomes across multiple organ systems, as well as increased mortality. However, the clinical significance of mild or moderate hypophosphataemia remains uncertain. This can lead...
 OTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174

05:02
Establishment of a chronic activity-based anorexia rat model
 OtoRhinoLaryngolgy News

05:02
Stimuli to differentiate the neural response at successive stages of visual processing using the VEP from human visual cortex
 Medicine….iliofanis
05:01
Preclinical development of CD38-targeted [89Zr]Zr-DFO-daratumumab for imaging multiple myeloma
Multiple myeloma (MM) is a plasma B-cell hematologic cancer that causes significant skeletal morbidity. Despite improvements in survival, heterogeneity in response remains a major challenge in MM. Cluster of differentiation 38 (CD38) is a type II transmembrane glycoprotein over-expressed in myeloma cells...
 Cancerology Oncology

05:01
How Should FDA Review Diagnostic Radiopharmaceuticals?
The purpose of this article is to reconsider the manner in which the U.S. Food and Drug Administration (FDA) reviews diagnostic radiopharmaceuticals. Mass characteristics of several common non-radioactive drugs and a number of diagnostic radiopharmaceuticals are considered. A history of the regulation...
 Cancerology Oncology

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