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Πέμπτη 8 Σεπτεμβρίου 2022

SARS‐CoV‐2 IgG “heritage” in newborn: a credit of maternal natural infection

alexandrossfakianakis shared this article with you from Inoreader

Abstract

Introduction

Description of transplacental passage of specific SARS-CoV-2 IgG from mothers who contracted natural infection to their newborns.

Methods

Retrospective cohort analysis including pregnant women diagnosed with SARS-CoV-2and their newborns both tested for SARS-CoV2 specific IgG and IgM with antibody titration at delivery. NPS were taken from both mothers and neonates, and tested for SARS-CoV-2 using PCR.

Results

IgM and IgG were analyzed in maternal and neonatal serum of 143 mother-infant dyads. 86% of women with a positive SARS-CoV-2 PCR > 14 days before delivery developed specific IgG and 84% of their infants showed transplacental passage of IgG.

Conclusions

Pregnant women infected with SARS-CoV-2 achieve antibody seroconversion following the kinetics described in the general population, and transplacental transfer of IgG specific antibodies occurs. No conclusion can be drawn on passive immunity efficacy or duration.

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