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Τετάρτη 1 Ιουνίου 2022

The usefulness of high‐risk HPV early oncoprotein (E6 and E7) serological markers in the detection of cervical cancer: A systematic review and meta‐analysis

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ABSTRACT

Background

We reviewed the literature on the importance of selected anti-HR-HPV-antibodies (namely16/18 and early oncoproteins, E6 and E7) as potential serological markers for early detection of individuals at high risk of cervical cancer.

Methods

We searched for studies in PubMed and Embase databases published from 2010 to 2020 on antibodies against HR-HPV E6 and E7 early proteins and cervical cancer. Pooled sensitivity and specificity for HPV-16 and -18 antibodies were calculated using a bivariate hierarchical random effect model.

Results

A total of 69 articles were identified; we included 3 studies with 1,550 participants. For the three HPV-16/18 E6 and E7 antibody tests, ELISA based assays had a sensitivity of detecting CIN2+ of 18 % (95% CI:15-21) and specificity of 96% (95% CI:92-98), and for Slot Blot sensitivity was 28.9% (95% CI: 23.3-35.1) and specificity 72% (95% CI:66.6-77.0) of detecting CIN2+ and for Multiplex HPV serology assay ba sed on a glutathione S-transferase (GST) sensitivity was 16% (95% CI:8.45-28.6) and specificity 98% (95% CI:97-99) for detecting ICC.

Conclusion

HR-HPV16/18 E6 and E7 serological markers showed high specificity but sensitivity was suboptimal for the detection of cervical cancer in either population screening settings or as point–of–care screening tests.

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