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Τρίτη 3 Μαΐου 2022

Incidence, etiology, risk factors and outcomes of pre‐engraftment bloodstream infections after first and second allogeneic hematopoietic cell transplantation

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Abstract

Introduction

With increasing number of allogeneic hematopoietic cell transplantations (allo-HCT) bloodstream infections (BSI) are still among the most common and serious complications. This study aimed to analyze the incidence, etiology, risk factors, and outcomes of pre-engraftment BSI after the first and the second allo-HCT.

Materials and methods

This is a retrospective study of 284 patients who underwent first allo-HCT and 37 patients after the second allo-HCT at the National Research Center for Hematology in Moscow, Russia, from January 2018 till September 2021.

Results

Cumulative incidence of pre-engraftment BSI was 29.9% after the first allo-HCT and 35.1% after the second (p = 0,805). Median time to the first BSI was 9 days (range 0–61 days) after the first and 16 days (range 1–28 days) after the second allo-HCT (p = 0.014). A total of 113 pathogens were isolated during 94 BSI episodes after the first allo-HCT (gram-negative bacteria 52.2%; gram-positive bacteria 47.7%). Fourteen pathogens were isolated during 14 BSI episodes after the second allo-HCT (gram-negative bacteria 50.0%; gram-positive bacteria 50.0%). The only significant difference was found in the rate of carbapenem-resistant gram-negative bacteria, which was higher after the second allo-HCT compared to the first (57.1% vs. 13.6%; p = 0.048).

Mismatched unrelated donor (HR 3.01; 95% CI:1.62-5.60; p<0.0001) and haploidentical donor transplantations (HR 1.84; 95% CI:1.02-3.33; p = 0.042) were the only independent risk factors associated with the higher risk of pre-engraftment BSI.

Overall 30-day survival after all BSI episodes was 94.4%,. Survival was lower after BSI during the second allo-HCT compared to the first (71.4% vs. 97.9%; p<0,0001), particularly after BSI caused by carbapenem-resistant gram-negative bacteria (25.0% vs. 100.0%; p = 0.0023). Non-relapse mortality rate at day +60 was 4.0%, and the risk was highly associated with primary graft failure (HR 9.62; 95% CI: 1.33-71.43), second allo-HCT (HR 6.80; 95% CI: 1.36-34.48), and pre-engraftment BSI caused by carbapenem-resistant gram-negative bacteria (HR 32.11; 95% CI: 4.91-210.15).

Conclusions

Pre-engraftment BSI is still a common complication after allo-HCT, particularly after mismatched unrelated and haploidentical donor transplantations. BSI incidence was slightly higher after the second allo-HCT with significantly higher rate of carbapenem-resistant BSI. Although pre-engraftment BSI would generally follow benign clinical course, survival was dramatically lower during the second allo-HCT especially after carbapenem-resistant BSI.

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