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Πέμπτη 10 Ιουνίου 2021

Dysphagia profiles after primary transoral robotic surgery or radiation for oropharyngeal cancer: A registry analysis

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Abstract

Objective

To describe the physiologic swallowing impairments (MBSImP™©) associated with safety/efficiency impairments (DIGESTsafety/DIGESTefficiency grades) at 3–6 months after transoral robotic surgery (TORS) or radiation therapy (RT).

Study Design

Secondary analysis of registry data.

Setting

Single, academic institution.

Methods

Two hundred and fifty-seven patients with HPV+ oropharynx cancer were stratified by primary treatment (75 TORS, 182 RT). Modified barium swallow studies were analyzed at baseline and 3–6 months using MBSImP scores and DIGESTsafety/DIGESTefficiency grades. DIGESTsafety/DIGESTefficiency grades and MBSImP were compared groupwise and associations between DIGESTsafety/DIGESTefficiency grades and MBSImP were explored by ordinal logistic regression. Exploratory analyses were stratified by multimodality treatment.

Results

Neither DIGESTsafety/DIGESTefficiency differed significantly between groups at baseline or 3–6 months. Laryngeal vestibule closure was impaired more frequently in the RT group (RT: 41% vs. TORS: 27%; p = 0.02) while the TORS group had significantly more pharyngeal contraction impairment (63%; p < 0.001) compared to RT at 3–6 months.

Conclusion

The results suggest a focal injury associated with DIGESTsafety/DIGESTefficiency post-TORS in contrast to a low-level diffuse physiologic impairment associated with post-RT dysphagia.

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