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Τρίτη 23 Φεβρουαρίου 2021

Clinical utility of procalcitonin in bacterial infections in patients undergoing hematopoietic stem cell transplantation

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Am J Blood Res. 2020 Dec 15;10(6):339-344. eCollection 2020.

ABSTRACT

BACKGROUND: Infections are major contributor to morbidity and mortality in patients undergoing bone marrow transplant (BMT).

OBJECTIVE: To assess role of serum procalcitonin (PCT) as a useful biomarker for the infections and outcomes in these patients.

METHODS: Retrospective observational study.

RESULTS: Total 47 patients with febrile episodes were enrolled. Twenty patients underwent autologous BMT and 27 underwent allogeneic BMT. Bacterial infections were documented in 18/47 (38%) patients. Forty patients were neutropenic. The median fever duration was 10 days (range 3-30 days) in positive procalcitonin level group whereas it was 4 days (range 1-18) in negative group. This was statistically significant (P=0.000). Procalcitonin levels were high in 8/9 episodes of sepsis (P=0.029). Intensive care unit transfers and death were significantly higher in PCT positive group as compared to PCT negative group.

CONCLUSION: Serum procalcitonin levels provide prognostic information of worse outcome in patients undergoing HSCT.

PMID:33489442 | PMC:PMC7811896

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