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Τρίτη 26 Ιανουαρίου 2021

Short‐term and long‐term unstimulated saliva flow following unilateral vs bilateral radiotherapy for oropharyngeal carcinoma

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Abstract

Background

We aimed to compare unstimulated saliva flow using 3‐minute modified Schirmer test (MST) following bilateral vs unilateral radiotherapy (RT) in oropharyngeal carcinoma (OPC).

Methods

We reviewed OPC patients treated with definitive intensity‐modulated radiation therapy (IMRT) between 2011 and 2017. MST was measured at baseline, 1‐/6‐/12‐/24‐month post‐RT. MST values were compared between bilateral‐RT vs unilateral‐RT groups. Multivariable logistic regression analysis (MVA) identified predictors of hyposalivation (MST < 25 mm).

Results

Total 498 bilateral‐RT and 36 unilateral‐RT patients were eligible. The MST values at 1‐/6‐/12‐/24‐month post‐RT were all significantly reduced from baseline for the entire cohort. Baseline unilateral‐RT and bilateral‐RT MST values (in mm) were similar (P = .2), but much higher for unilateral‐RT 1‐month (mean: 19.1 vs 13.0, P = .03), 6‐month (20.5 vs 9.3, P < .001), 12‐month (20.1 vs 11.9, P < .01), and 24‐month post‐RT (22.2 vs 13.9, P = .04). MVA confirmed that unilateral RT reduced the likelihood of hyposalivation vs bilateral RT (OR 2.36, P = .006).

Conclusion

Unilateral RT reduces unstimulated salivary flow in OPC patients.

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