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Τετάρτη 9 Δεκεμβρίου 2020

Alimentary System is Directly Attacked by SARS-COV-2 and Further Prevents Immune Dysregulation Caused by COVID-19.

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Alimentary System is Directly Attacked by SARS-COV-2 and Further Prevents Immune Dysregulation Caused by COVID-19.

Int J Clin Pract. 2020 Dec 07;:e13893

Authors: Chen S, Zhou J, Ou X, Cheng W, Qin Y, Guo Y, Jiang Y

Abstract
BACKGROUND: SARS-COV-2 causes digestive system symptom, the effect of which remains equivocal.
METHODS: Patients with COVID-19 were classified into 4 groups according to symptom. The study traced the onset and duration of symptoms, compared laboratory examinations and conducted bioinformatic analysis. Immune indices were further analyzed.
RESULTS: By March 16, 25 patients with COVID-19 and 13 with suspect COVID-19 were admitted to West China Hospital, Sichuan University. Digestive system symptom group had the highest level of ESR (mm/h, P<0.0001), serum ferritin (ng/ml, P<0.0001), hepatic enzymes (P<0.05), and retentive lymphocyte count/percentage (P<0.05) and its subsets (P<0.05). Combined group (respiratory combined with subsequent digestive system symptom) had the highest level of IL-6 (pg/ml, P=0.0046), CRP (mg/L, P=0.0004) and moderate lymphocyte depletion. Respiratory system symptom and asymptomatic groups suffered the most from lymphocyte depletion (P<0.05). Bioinformatic analysis indicated co-expression of binding related proteins of SARS-COV-2 (ACE2, TMPRSS2 and Furin) in small intestine. CD147 was extensively expressed in alimentary tract. CTSL, PIKfyve, TPC2 and CTSB could be detected with ≥moderate expressions in a variety of organs including alimentary system.
CONCLUSIONS: Alimentary system is possibly attacked by SARS-COV-2 other than hyperinflammation or immune dysregulation caused by it. Involvement of alimentary system might further protect mild and moderate cases from lymphocyte depletion caused by COVID-19.

PMID: 33289233 [PubMed - as supplied by publisher]

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