COVID-19 in Lung Transplant Recipients

alexandrossfakianakis shared this article with you from Inoreader COVID-19 in Lung Transplant Recipients Via Transplantation - Published Ahead-of-Print Background: A concern about the susceptibility of immunocompromised patients to the worldwide pandemic of coronavirus disease 2019 (COVID-19) has been raised. We aimed at describing COVID-19 infections in the French cohort of lung transplant (LT) patients. Methods: Multicenter nationwide cohort study of all LT recipients with COVID-19 diagnosed from March 1 to May 19, 2020. Recipient main characteristics and their management were retrieved. Hospitalization characteristics, occurrence of complications and survival were analyzed. Results: Thirty-five LT patients with a COVID-19 infection were included. Median age was 50.4 [40.6-62.9] years, 16 (45.7%) were female, and 80% were double-LT recipients. Infection was community-acquired in 25 (71.4%). Thirty-one (88.6%) required hospitalization, including 13 (41.9%) in the intensive care unit. The main symptoms of COVID-19 were fever, cough, and diarrhea, present in 71.4%, 54.3%, and 31.4% of cases, respectively. Extension of pneumonia on chest CT was moderate to severe in 51.4% of cases. Among the 13 critically ill patients, 7 (53.9%) received invasive mechanical ventilation. Thrombotic events occurred in 4 patients. Overall survival rate was 85.7% after a median follow-up of 50 days [41.0-56.5]. Four of 5 nonsurvivors had had bronchial complications or intensification of immunosuppression in the previous weeks. On univariate analysis, overweight was significantly associated with risk of death (odds ratio 16.0 [95% confidence interval1.5-170.6], p=0.02). Conclusion: For the 35 LT recipients with COVID-19, the presentation was severe, requiring hospitalization in most cases, with a survival rate of 85.7%. Financial Disclosure: None Disclaimer: JM declares congress reimbursement fees from Fisher&Paykel, and CSL Behring. JFM declares fees from LFB, CSL Behring, Actelion, Astra Zeneca, Bayer, Boehringer Ingelheim, Chiesi, GSK, LFB Biomédicaments, MSD, Mundi Pharma, Novartis, Pfizer, Roche. NC reports non-financial support from Mylan, Novartis, Herakos. HM reports grants from Pfizer and fees from Novartis, and Boehringer. Correspondence: Jonathan Messika, MD, PhD Service de Pneumologie B et Transplantation Pulmonaire APHP.Nord-Université de Paris, Hôpital Bichat-Claude Bernard 46 rue Henri Huchard 75018 Paris, France Tel +33140256919 Fax +33140256104 Email: jonathan.messika@aphp.fr Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.