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Δευτέρα 30 Νοεμβρίου 2020

Autofluorescence and Indocyanine Green in Thyroid Surgery: A Systematic Review and Meta‐Analysis

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Objectives/Hypothesis

To estimate the impact of optical techniques on prevention of post‐operative hypocalcemia and hypoparathyroidism after total thyroidectomy.

Study Design

Systematic review and meta‐analysis.

Methods

A literature search was conducted in Pubmed, EMBASE, SCOPUS, and Cochrane databases. The main inclusion criteria for eligible articles for meta‐analysis were patients with benign or malignant thyroid pathologies who underwent total thyroidectomy, utilization of optical techniques to support PGs preservation, the availability of calcium and/or PTH levels. The primary outcome was to evaluate the variation of calcium and PTH levels when adopting optical technologies compared to standard naked‐eye surgery.

Results

In total, 13 papers with 1484 procedures were included. Pooled proportion for short‐ and medium‐term hypocalcemia rates were 8% (95% CI, 5%:11%) and 1% (95% CI, 0%:4%) for optical techniques, while for naked‐eye surgery were 15% (95% CI, 9%:23%) and 5% (95% CI, 2%:9%), respectively.

Conclusions

Optical technologies reduced short and medium term hypocalcemia compared to conventional surgery.

Level of Evidence

NA Laryngoscope, 2020

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