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Κυριακή 31 Μαρτίου 2019

Therapeutics

β-N-Oxalyl-L-α,β-diaminopropionic acid from <em>Panax notoginseng</em> plays a major role in the treatment of type 2 diabetic nephropathy
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Jie Li, Pengcheng Qiu, Siwang Wang, Junsheng Wu, Qiaoyan He, Kaifeng Li, Lu XuAbstractBackgroundDiabetic nephropathy (DN) is one of the most serious and dangerous chronic complications of diabetes mellitus.Panax notoginseng has been widely used with great efficacy in the long-term treatment of kidney disease. However, the mechanism by which it exerts its effects has not been fully elucidated.AimWe sought to...
Biomedicine & Pharmacotherapy
Fri Mar 29, 2019 16:56
The protective effects of 1,2-propanediol against radiation-induced hematopoietic injury in mice
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Lirong Yi, Mei Tian, Chunnan Piao, Gang Gao, Lina Wu, Yan Pan, Jianxiang LiuAbstractAgents that provide protection against irradiation-induced hematopoietic injury are urgently needed for radiotherapy. We examined the effects of the small molecule, 1,2-propanediol (PPD), on total body irradiation (TBI)-induced hematopoietic injury in C57BL/6 mice. PPD administration 1 h before TBI significantly increased hematopoietic...
Biomedicine & Pharmacotherapy
Fri Mar 29, 2019 16:56
Editorial Board
Publication date: May 2019Source: Biomedicine & Pharmacotherapy, Volume 113Author(s):
Biomedicine & Pharmacotherapy
Fri Mar 29, 2019 16:56
Issue Information
Clinical and Translational Science
Fri Mar 29, 2019 18:21
Surgical Options for Locally Advanced Oropharyngeal Cancer
Opinion statement Oropharyngeal squamous cell carcinoma (OPSCC) incidence rates have been steadily increasing over the past several decades, and this has been largely attributed to human papillomavirus (HPV)-related OPSCC. The rise of HPV-related OPSCC and the observed distinct survival advantage it offers compared to HPV-unrelated OPSCC have resulted in the development of a new staging system specifically for OPSCC in the eighth edition of the AJCC Staging Manual for head and...
Current Treatment Options in Oncology
03:00
Antibody-Drug Conjugates in Breast Cancer: a Comprehensive Review
Opinion Statement Antibody-drug conjugates are an elegant approach to cancer treatment that couples the specificity of monoclonal antibodies to the cytotoxicity of classic chemotherapy agents, permitting, at least in theory, increased activity and reduced toxicity. In breast cancer, the early success of trastuzumab-emtansine (T-DM1) in the HER2-positive metastatic setting led to great hopes, later dashed by results in the early setting (KRISTINE trial) and in combination with...
Current Treatment Options in Oncology
03:00
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography
Publication date: Available online 30 March 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Yen-Jen Wang, Yen-Kai Huang, Jen-Yu Wang, Yu-Hung Wu
Photodiagnosis and Photodynamic Therapy
Sun Mar 31, 2019 12:50
Influence of phototherapy on bond strength and failure modes of enamel bonded to ceramic and metallic brackets with different surface treatment regimes
Publication date: Available online 30 March 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Salem AlmoammarAbstractAimThe aim of the current study was to assess efficacy of phototherapy on mode of failure and shear bond strength among different brackets in combination with dissimilar conditioning regimens on enamel surfaceMaterial and methodsNinety maxillary premolars were arbitrarily assigned into six groups (n = 15 each) based on surface conditioning of enamel. Group 1 and group 2...
Photodiagnosis and Photodynamic Therapy
Sat Mar 30, 2019 15:52
Contents
Radiotherapy and Oncology
Sat Mar 30, 2019 04:04
A Timely Multidisciplinary Update on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Publication date: Available online 30 March 2019Source: Clinical TherapeuticsAuthor(s): Theoharis C. Theoharides
ScienceDirect Publication: Clinical Therapeutics
Sun Mar 31, 2019 17:25
Derivation and Evaluation of the Ischemic Risk Model in High-Risk Chinese Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome
Publication date: Available online 29 March 2019Source: Clinical TherapeuticsAuthor(s): Yanguo Xin, Yinan Zhao, Xin Chen, Junli Li, Zhiyue Liu, Xiaofan Cao, Yingxian Sun, Wenyu HuAbstractPurposeCoronary artery disease is the top cause of death among the Chinese population. With the establishment of a Chinese prediction model, it is urgent to assess factors related to the prognosis of patients with acute coronary syndrome at extremely high risk.MethodsIn this retrospective study, we enrolled 601 patients...
ScienceDirect Publication: Clinical Therapeutics
Sat Mar 30, 2019 16:04
Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome
Publication date: Available online 28 March 2019Source: Clinical TherapeuticsAuthor(s): Matthew C. Morris, Katherine E. Cooney, Hooman Sedghamiz, Maria Abreu, Fanny Collado, Elizabeth G. Balbin, Travis J.A. Craddock, Nancy G. Klimas, Gordon Broderick, Mary Ann FletcherAbstractPurposeThe complex and varied presentation of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has made it difficult to diagnose, study, and treat. Its symptoms and likely etiology involve multiple components of endocrine...
ScienceDirect Publication: Clinical Therapeutics
Fri Mar 29, 2019 14:12
Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy
Publication date: Available online 28 March 2019Source: Clinical TherapeuticsAuthor(s): Edwin Lam, Ankit Rochani, Gagan Kaushal, Brandi N. Thoma, Julian Tanjuakio, Frances Mae West, Hitoshi HiroseAbstractPurposeFirst-line management of severe asthma exacerbations include the use of inhaled short-acting β-agonists, anticholinergics, and systemic corticosteroids. Continuous intravenous ketamine given at dissociative doses may be a pharmacologic option in patients who are intubated with life-threatening...
ScienceDirect Publication: Clinical Therapeutics
Fri Mar 29, 2019 14:12
Table of Contents
Publication date: March 2019Source: Clinical Therapeutics, Volume 41, Issue 3Author(s):
ScienceDirect Publication: Clinical Therapeutics
Fri Mar 29, 2019 14:12
The levels and significance of inflammasomes in the mouse retina following optic nerve crush
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Zheng Qijun, Zou Huan, Gao Ling, Chen Kaijian, Liu Wei, Ji Shuxing, Chu Xiang, Yuan Rongdi, Ye JianAbstractInflammasomes play an important role in neuroinflammation. However, their function during the secondary death of retinal cells after traumatic optic neuropathy and their dependence on pathogen stimuli remains unclear. Therefore, we evaluated the expression profiles of 10 different inflammasome-related mRNAs...
ScienceDirect Publication: International Immunopharmacology
Sun Mar 31, 2019 14:47
Protective effects of ambroxol in psoriasis like skin inflammation: Exploration of possible mechanisms
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Shruthi Sunkari, Sowjanya Thatikonda, Venkatesh Pooladanda, Veerabhadra Swamy Challa, Chandraiah GoduguAbstractThe purpose of this study was to investigate the protective effects of ambroxol in psoriasis-like skin inflammation both in vitro and in vivo and delineate the molecular mechanism of ambroxol. Our data demonstrated that ambroxol has an imperative role in inhibiting the lipopolysaccharide (LPS) stimulated...
ScienceDirect Publication: International Immunopharmacology
Sat Mar 30, 2019 12:31
3′UTR variants of <em>TNS3</em>, <em>PHLDB1</em>, <em>NTN4</em>, and <em>GNG2</em> genes are associated with IgA nephropathy risk in Chinese Han population
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Yuan Feng, Yan Su, Chunyang Ma, Ziyang Jing, Xiaohong Yang, Daofa Zhang, Maowei Xie, Wenning Li, Jiali WeiAbstractBackgroundImmunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis and is characterized by mesangial cell proliferation and agglomeration of the mesangial matrix.MethodsIn this study, we aimed to explore the role of TNS3, PHLDB1, NTN4, and GNG2 3′untranslated region (3′UTR)...
ScienceDirect Publication: International Immunopharmacology
Fri Mar 29, 2019 15:17
MiR-155 controls follicular Treg cell-mediated humoral autoimmune intestinal injury by inhibiting CTLA-4 expression
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Gao Chao, Xiaoli Li, Yahong Ji, Ying Zhu, Na Li, Nana Zhang, Zunyong Feng, Min NiuAbstractHigh expression levels of miR-155 are involved in the pathogenesis of inflammatory bowel disease (IBD). We observed an increase in miR-155 in peripheral regulatory T (Treg) cells from IBD patients. Mice that specifically overexpress miR-155 in Foxp3+ Treg cells exhibit spontaneous autoimmunity and more severe dextran sulfate...
ScienceDirect Publication: International Immunopharmacology
Fri Mar 29, 2019 15:17
Network pharmacology-based identification of the protective mechanisms of taraxasterol in experimental colitis
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Wei Chen, Wei Da, Chen Li, Huining Fan, Rui Liang, Junqing Yuan, Xiaoqing Huang, Renzhi Yang, Jing Zhang, Jinshui ZhuAbstractBackground and aimTaraxasterol, a pentacyclic-triterpene, has been reported to exert potent anti-inflammatory activity. However, the molecular mechanisms by which taraxasterol attenuates acute experimental colitis (AEC) remain undocumented.MethodsA network pharmacology approach was used...
ScienceDirect Publication: International Immunopharmacology
Fri Mar 29, 2019 15:17
α-Difluoromethylornithine suppresses inflammatory arthritis by impairing myeloid-derived suppressor cells
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Zhe Geng, Bingxia Ming, Shaoxian Hu, Lingli Dong, Cong YeAbstractObjectivesThe chemopreventive drug α-difluoromethylornithine (DFMO) has been shown to have an antinociceptive effect on mechanical allodynia in inflammatory arthritis by directly inhibiting ornithine decarboxylase (ODC) and decreasing polyamine production in inflammatory sites. However, little is known about the effect of DFMO on the immune system...
ScienceDirect Publication: International Immunopharmacology
Fri Mar 29, 2019 15:17
Isoflavone daidzein regulates immune responses in the B6C3F1 and non-obese diabetic (NOD) mice
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Guannan Huang, Joella Xu, Tai L. GuoAbstractDaidzein (DAZ), a dominant isoflavone in various natural products such as soybeans, has been gaining attention due to the beneficial health effects (e.g., protection against cancer and diabetes) of its metabolites. Our major hypothesis was that dietary exposure to the soy phytoestrogen DAZ could modulate the immune responses toward a protective effect and lead to improved...
ScienceDirect Publication: International Immunopharmacology
Fri Mar 29, 2019 15:17
Purification and characterization of a novel immunomodulatory lectin from <em>Artocarpus hypargyreus Hance</em>
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Qiyan Zeng, Faquan Lin, Linjie Zeng, Yong Deng, Lu LiAbstractLectins are proteins/glycoproteins of non-immune origin, which interact specifically and non-covalently with the carbohydrate moieties of respective receptors on the cell surface. In this study, a novel 65.2-kDa tetrameric lectin (AHL) was purified from Artocarpus hypargyreus Hance (A. hypargyreus) by affinity chromatography on a galactose-sepharose...
ScienceDirect Publication: International Immunopharmacology
Fri Mar 29, 2019 15:17
Improving the quality of myofascial release research – A critical appraisal of systematic reviews
Publication date: Available online 29 March 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): M.S. Ajimsha, Pramod D. ShenoyAbstractIntroductionMyofascial release (MFR) is a form of manual therapy that involves the application of a low load, long duration stretch to the myofascial complex intended to restore optimal length, decrease pain and improve function. MFR is being used to treat patients with a wide variety of conditions with favourable evidence supporting its efficacy. Critical...
ScienceDirect Publication: Journal of Bodywork and Movement Therapies
Fri Mar 29, 2019 13:54

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