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Πέμπτη 10 Ιανουαρίου 2019

Carbimazole-induced agranulocytosis

 – A rare case report p. 305
R Siddeswari, Sikandar Mohan, K Swamy
DOI:10.4103/JDRNTRUHS.JDRNTRUHS_60_18  
A 30-year-old lady with hyperthyroidism for the past 1 year was initially on carbimazole 30 mg twice orally and then changed to 30 mg once daily. She presented with intermittent fever since 3 weeks, h/o oral ulcers, difficulty in swallowing, and palpitations. Routine investigations showed anemia, neutropenia, leucopenia, and C-reactive protein elevation. Peripheral smear showed normocytic normochromic anemia with leucopenia. Widal test, RA factor test, immunoglobulin M (Ig M) dengue, Ig M Lepto, antinuclear antibody screen, cytoplasmic antineutrophil cytoplasmic antibodies, and perinuclear anti-neutrophil cytoplasmic antibodies tests were negative. Viral markers are negative.
http://www.jdrntruhs.org/currentissue.asp?sabs=y

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