Publication date: Available online 13 December 2018
Source: Auris Nasus Larynx
Author(s): Elif Koclu Hetemoglu, Seda Turkoglu Babakurban, Yunus Kasım Terzi, Feride Iffet Sahin, Selim Sermed Erbek
Abstract
Objective
Fractalkine, member of chemokine family, is involved in many inflammatory processes in the human body. The aim of this study is to compare expression levels of fractalkine ligand and its receptor in chronic tonsillitis and hypertrophic tonsil samples.
Methods
The study was conducted at Baskent University Departments of Otorhinolaryngology and Medical Genetics. It is designed as a prospective, non-randomized, controlled clinical study. Total 97 samples, obtained from adenotonsillectomy due to chronic tonsillitis or tonsillar hypertrophy, were participated in the study. Fractalkine and its receptor expression levels were determined and comparison was made between the tissue groups. c.839C > T (T280 M) polymorphism of fractalkine receptor was analyzed, then relationship between polymorphism and the expression level of fractalkine receptor was investigated.
Results
Fractalkine receptor expression was significantly higher in the hypertrophic tonsil group than chronic tonsillitis group (p < 0.05).
Conclusion
Fractalkine, member of chemokine family, and its receptor may play role in preventing chronic-recurrent tonsillitis.
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