Publication date: Available online 1 October 2018
Source: Journal of the American Academy of Dermatology
Author(s): Yik Weng Yew, Jacob P. Thyssen, Jonathan I. Silverberg
Abstract
Background
Previous studies found conflicting results about the commonality of different atopic dermatitis (AD) signs and symptoms.
Objective
To determine the prevalences of AD characteristics and differences by region and age.
Methods
A systematic review was performed of all published studies in MEDLINE, EMBASE, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan electronic periodical services and CiNii that analyzed the proportion of AD characteristics. Two reviewers performed study title/abstract review and data abstraction.
Results
One hundred and one studies reported proportion of AD features with sufficient data for meta-analysis. The most prevalent AD features were pruritus, lichenification and xerosis. There were differences of AD characteristics by study region. Flexural involvement was less commonly reported in India, America and Iran. East Asian studies reported more erythroderma, truncal, extensor, scalp and auricular involvement. Southeast Asian studies reported more exudative eczema, truncal involvement, lichenification and prurigo nodules. Studies from Iran reported more head, face and neck involvement, pityriasis alba, and xerosis. Studies from Africa reported more papular lichenoid lesions, palmar hyperlinearity, ichthyosis and orbital darkening.
Limitations
Heterogeneity between studies and limited reporting of certain AD clinical characteristics.
Conclusions
AD characteristics are heterogeneous and vary by region and age.
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