Therapeutic effects of simultaneous Photobiomodulation therapy (PBMT) and Meloxicam administration on experimental acute spinal cord injury: Rat animal model

Publication date: Available online 29 September 2018

Source: Journal of Photochemistry and Photobiology B: Biology

Author(s): Mir Sepehr Pedram, Mohammad Mehdi Dehghan, Maryam Shojaee, Reza Fekrazad, Davood Sharifi, Arash Farzan, Setareh Ghasemi, Katayoun AliMohammad Kalhori

Abstract

Study design

Application of Photobiomodulation therapy (PBMT) and meloxicam in acute spinal cord injury, functional recovery and histological evaluation.

Objective

Evaluation of the effect of simultaneous PBMT and meloxicam on treatment of acute experimental spinal cord injury and comparing it with the effect of application of each of them separately.

Setting

The study was conducted at the Department of Surgery & Radiology and Biomedical Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Methods

24 rats were used in this study. A compression injury was induced to the T8-T9 segment of the spinal cord of rats using a Fogarty embolectomy catheter. Rats were randomly divided into 4 groups including: Control group, PBMT (810 nm-200 mw-8 s-2 weeks) group, Meloxicam (1 mg/kg) group, and PBMT and Meloxicam (mixed) group. After inducing injury, hind limb performance of the rats was evaluated, using BBB test and then treatment intervention was performed and continued for 2 weeks.

Results

4 weeks after injury induction, BBB test results were significantly higher in all treatment groups in comparison to control group, however, there were no significant differences among the treatment groups. In addition, histological findings revealed no significant difference between all 4 study groups.

Conclusion

According to the results of this study we can conclude that simultaneous and separate application of PBMT and Meloxicam play an effective role in treatment of acute spinal cord injuries.