Relationship between pruritus and quality of life in patients with atopic dermatitis treated with crisaborole

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous lesions and pruritus. Pruritus can lead to exacerbation of disease and reduced quality of life (QoL). Crisaborole ointment is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate AD. Compared with vehicle, use of crisaborole significantly reduced global disease severity and pruritus in 2 large, identically designed phase 3 clinical studies (AD-301: NCT02118766; AD-302: NCT02118792).