Endoglin is highly expressed in human mast cells

Background: CD 105 is a glycoprotein of cell membrane, for which an immunohistochemical antibody has been used as marker of endothelial cells from capillaries in proliferation. Mast cells originate from hematopoietic stem cells located in the bone marrow and migrate through the blood stream to target tissues. These cells are a component of normal tissue, though they play an important role in the regulation of several processes, including inflammation, allergy and neoplasia. The aim of this study was to evaluate the use of CD105 as a biologic marker of mast cells compared with the criterion standard stain.