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Δευτέρα 9 Ιουλίου 2018

Diffusion-Weighted Imaging and Diffusion Tensor Imaging for Differentiating High-Grade Glioma from Solitary Brain Metastasis: A Systematic Review and Meta-Analysis [ADULT BRAIN]

BACKGROUND:

Accurate diagnosis of high-grade glioma and solitary brain metastasis is clinically important because it affects the patient's outcome and alters patient management.

PURPOSE:

To evaluate the diagnostic performance of DWI and DTI for differentiating high-grade glioma from solitary brain metastasis.

DATA SOURCES:

A literature search of Ovid MEDLINE and EMBASE was conducted up to November 10, 2017.

STUDY SELECTION:

Studies evaluating the diagnostic performance of DWI and DTI for differentiating high-grade glioma from solitary brain metastasis were selected.

DATA ANALYSIS:

Summary sensitivity and specificity were established by hierarchic logistic regression modeling. Multiple subgroup analyses were also performed.

DATA SYNTHESIS:

Fourteen studies with 1143 patients were included. The individual sensitivities and specificities of the 14 included studies showed a wide variation, ranging from 46.2% to 96.0% for sensitivity and 40.0% to 100.0% for specificity. The pooled sensitivity of both DWI and DTI was 79.8% (95% CI, 70.9%–86.4%), and the pooled specificity was 80.9% (95% CI, 75.1%–85.5%). The area under the hierarchical summary receiver operating characteristic curve was 0.87 (95% CI, 0.84–0.89). The multiple subgroup analyses also demonstrated similar diagnostic performances (sensitivities of 76.8%–84.7% and specificities of 79.7%–84.0%). There was some level of heterogeneity across the included studies (I2 = 36%); however, it did not reach a level of concern.

LIMITATIONS:

The included studies used various DWI and DTI parameters.

CONCLUSIONS:

DWI and DTI demonstrated a moderate diagnostic performance for differentiation of high-grade glioma from solitary brain metastasis.



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