(R)-(+)-pulegone suppresses allergic and inflammation responses on 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice model

Atopic dermatitis (AD) is a type of inflammatory skin disease, which affects from infants and adolescents to adults in developed countries [1]. Although AD is not a life-threatening disease, it remains a serious health problem and the incidence rates of AD is still increasing worldwide [2]. AD patients exhibit the eczematous lesions, itching, destruction of epidermal barrier, and inflammatory cell infiltration of the dermis [3]. The pathology of AD has not been fully defined, it has been implicated to involve in complex interactions of genetic, immune and environmental factors [4].