Anesthesia for collagenase clostridium histolyticum injection in patients with dupuytren disease: A cohort analysis.

Procedural pain is one of the most common adverse effects reported by patients with Dupuytren disease treated with collagenase clostridium histolyticum (CCH). The aim of this study was to assess the effectiveness of wrist block prior to CCH injection in reducing procedural pain and analyze its impact on adverse effects. We performed a prospective, single-centre study in which we compared two groups of patients in a consecutive cohort. In the first group (NO-BLOCK), wrist block was only performed before finger extension, while in the second group (BLOCK) it was performed before CCH injection and finger extension.