EGFR transactivation is involved in TNF-α-induced expression of thymic stromal lymphopoietin in human keratinocyte cell line

Thymic stromal lymphopoietin (TSLP), a paralog of Interleukin (IL)-7, is involved in inflammatory skin disorders, such as atopic dermatitis and psoriasis. TSLP activates dendritic cells to produce Th2 chemokines and is highly expressed in the epithelium in the skin of patients with atopic dermatitis [1]. TSLP receptor deficiency attenuates IL-4, IL-13, and IgE production in ovalbumin-sensitized mice [2]. Thus, TSLP is considered as the master cytokines of allergy [3]. In addition, Elisabetta et al.