EPID-13. A SINGLE INSTITUTION ANALYSIS: DETERMINING GENETIC VARIATION AND SURVIVAL OUTCOMES AMONG ASIAN AND NON-ASIAN NEUROSURGERY PATIENTS

Abstract

BACKGROUND

Globally, brain cancer compromises 2% of all total emerging cancers, yet has one of the lowest survival five-year survival rates. Differences in clinical outcomes between brain tumor patients of different races remains poorly understood.

METHODS

A retrospective chart review was performed on brain tumor resection patients 18 years old. Demographics, treatment variables, and survival outcomes were collected. Primary outcomes were recurrence rate, progression free survival (PFS), and overall survival (OS).

RESULTS

A total of 666 patients were included in final analysis. Females and males had nearly a 1:1 ratio (n = 345 and n = 321, respectively). Mean age was 51.3 (± 17.2) years. Females composed 64.3% (n = 54) of Asians patients; males constituted 35.7% (n = 30). Mean age of the Asians was 53.5 (± 16.5) years. Tumor pathologies included meningioma (n = 210 total) and glioblastoma (n = 192 total). There were 210 meningioma patients, of which Non-Asian patients comprised 81.43% of the group (n = 171) and Asian patients composed 18.57% (n = 39). We identified 192 glioblastoma patients in total. Non-Asian patients made up 92.7% of the glioblastoma cohort (n = 178) with the remaining 7.3% (n = 14) composed of Asian patients. There were no statistically significant differences between these groups in both cohorts in recurrence (P = .9052 and P = .7894, respectively), PFS (P = .6953 and P = .845, respectively), or OS (P = 1.0 and P = .9126, respectively).

CONCLUSION

Studies evaluating the survival between patients of different racial backgrounds against several tumor varieties are rare. Patients of certain racial backgrounds may need additional care consideration despite the same mutational composition as their counterparts. Repeated studies using national databases, such as the SEER database, may yield more conclusive results.