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Τετάρτη 27 Σεπτεμβρίου 2017

Medicine by Alexandros G. Sfakianakis


OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
The Effect of Manufacturing Techniques on Custom-Made Titanium Cranioplasty Plates: A Pilot Study
 
This study investigated the effect of varying techniques on the surface characteristics of pressed titanium cranioplasty plates, commonly manufactured in laboratory practice. The aim was to highlight the variety of techniques currently used, assess these methods of manufacture and produce manufacturing...
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Investigation of magnetic field effects on the dose–response of 3D dosimeters for magnetic resonance – image guided radiation therapy applications
 
The strong magnetic field of integrated magnetic resonance imaging (MRI) and radiation treatment systems influences secondary electrons resulting in changes in dose deposition in three dimensions. To fill the need for volumetric dose quality assurance, we investigated the effects of strong magnetic fields...
THERAPY MEDICINE BY SFAKIANAKIS G.ALEXANDROS
Preliminary results of the association of Palbociclib and radiotherapy in metastatic breast cancer patients
 
There are no published data of the tolerance of combination of Palbociclib and radiotherapy (Palbo-RT). The use of Palbociclib was recently authorized in France for metastatic hormonal receptor (HR) positive HER2 negative breast cancer in association with hormonal therapy in post-menopausal women. A...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Editorial Board
 
Publication date: October 2017Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 134, Issue 5 from #ORL via xlomafota13 on Inoreader http://ift.tt/2wVrLmF
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Contents
 
Publication date: October 2017Source:European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 134, Issue 5 from #ORL via xlomafota13 on Inoreader http://ift.tt/2xD2Hhp
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Phonation Analysis Combined with 3D Reconstruction of the Thyroarytenoid Muscle in Aged Ovine Ex Vivo Larynx Models
 
The aim of the study was to establish a basic data set of combined functional and anatomical measures of aged sheep larynges using ex vivo models. Combining these two approaches in one and the same larynx is an unmet goal so far yet is important as newer treatment strategies aim to preserve the organ...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Correspondence] Finding gold in tumour immunotherapy
 
I read with interest the recent Editorial1 in The Lancet Oncology. The Editorial suggested that immunotherapy is being overhyped and offering false hope to patients with cancer. In the Editorial, advances in immunotherapy were likened to drug developments for EGFR and VEGF inhibitors, which were rolled...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Correspondence] Rituximab and autologous stem-cell transplantation for high-risk diffuse large B-cell lymphoma – Authors' reply
 
The results from our randomised phase 3 trial1 showed that young patients, affected by high-risk diffuse large B-cell lymphoma (age-adjusted International Prognostic Index score of 2–3), who received abbreviated rituximab-dose-dense chemotherapy plus high dose therapy and autologous stem-cell transplantation...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Cancer and Society] A family chronicle of love and death
 
When Nancy Borowick’s father was diagnosed with cancer in 2012, her mother had already been battling the disease for 15 years. Both now had terminal diagnoses, and Borowick, a documentary photographer, set about recording their final months together. The Family Imprint is a handsome book containing these...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Clinical Picture] Obstructive sleep apnoea as a presenting manifestation of non-Hodgkin lymphoma in a child
 
A 14-year-old previously healthy adolescent male patient presented at Rady Children’s Hospital (San Diego, CA, USA) in July, 2016, with a history of worsening snoring, recurrent nocturnal awakenings, and daytime somnolence over an 8-month period. Notably, the patient was not overweight or obese; by contrast,...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Series] Assessment of cancer control capacity and readiness: the role of the International Atomic Energy Agency
 
During the past six decades, the International Atomic Energy Agency (IAEA) has helped to address the growing cancer burden, by delivering substantial cancer-related assistance to low-income and middle-income member states. IAEA assistance has primarily been facilitated through sustainable radiotherapy...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Cancer and Society] Edinburgh Festival Fringe Roundup
 
Cancer is not one disease but hundreds—not one emperor of maladies but an empire of related conditions sprawling through the human body. Perhaps reflecting that fact, most Edinburgh Fringe Festivals see a glut of shows about cancers of various stripes. Each Fringe exhibits several medically themed shows,...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Comment] Cancer in Peru: a detailed examination
 
In 2013, we published a Commission titled, Planning cancer control in Latin America and the Caribbean1 that highlighted the potential harms of an increasing cancer epidemic in a region where infrastructure and funding is ill-equipped to cope with non-communicable diseases. The Commission also detailed...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Series] Resource-stratified implementation of a community-based breast cancer management programme in Peru
 
Breast cancer incidence and mortality rates continue to rise in Peru, with related deaths projected to increase from 1208 in 2012, to 2054 in 2030. Despite improvements in national cancer control plans, various barriers to positive breast cancer outcomes remain. Multiorganisational stakeholder collaboration...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Cancer and Society] Pharma funding and breast cancer advocacy: the secret war
 
In Health Advocacy Inc, Sharon Batt chronicles what she dubs the breast cancer advocacy movement’s “secret war”: the fracturing of the movement over the contentious issue of whether to accept funding from pharmaceutical companies (pharma). from Cancer via xlomafota13 on Inoreader http://ift.tt/2xLcJ23
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Series] The implementation of the Plan Esperanza and response to the imPACT Review
 
Following the implementation of the National Cancer Prevention and Control Results-based Budget Programme (PpR Cancer–024) in 2011, the Peruvian Government approved the Plan Esperanza—a population-based national cancer control plan—in 2012. Legislation that ensured full government-supported funding for...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Series] Cancer patterns, trends, and transitions in Peru: a regional perspective
 
Peru, like several other South American countries, is experiencing remarkable population growth, ageing, and urbanisation, which has given rise to profound changes in its epidemiological profile. Prostate and breast cancer are the most frequent cancers in men and women, respectively, in Lima and Arequipa,...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
[Correspondence] Is it time to convert the frequency of radiotherapy in small-cell lung cancer?
 
In June, 2017, Corinne Faivre-Finn and colleagues reported the results of the CONVERT trial,1 which adds great value to management guidance for patients with small-cell lung cancer. They reported that once-daily radiotherapy (66 Gy in 33 fractions) did not differ from twice-daily radiotherapy (45 Gy...
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Sharing the SAGA
 
Publication date: Available online 27 September 2017Source:Trends in Biochemical Sciences ...
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Regulation of the Hippo Pathway Transcription Factor TEAD
 
Publication date: Available online 27 September 2017Source:Trends in Biochemical Sciences ...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Sleep-dependent motor sequence memory consolidation in individuals with periodic limb movements
 
Periodic limb movements (PLMs) during sleep increase with age and are associated with striatal neurodegeneration and dopamine deficiency. Limb movements are often associated with disruptions to non-rapid eye movement (NREM) sleep. Motor skill memory consolidation recruits the striatum, and learning-dependent...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Safety and efficacy of early feeding based on clinical assessment at 4 hours after ERCP: a prospective randomized controlled trial
 
The optimal timing of refeeding after ERCP is unknown. Some practices keep fasting for 24 hours after ERCP whereas others resume feeding earlier. We aimed to evaluate the risk of post-ERCP pancreatitis (PEP) in patients who initiate early feeding based on their clinical assessment, including serum amylase...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Self-expandable metal stent for malignant esophagorespiratory fistula: predictive factors associated with clinical failure
 
Malignant esophagorespiratory fistula (MERF) has been usually managed by the placement of self-expandable metal stent (SEMS) with conflicting results. This study aimed to identify risk factors associated with clinical failure after SEMS placement for the treatment of MERF. from Endocrinology via xlomafota13...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy
 
Abstract It is very well known that bone marrow (BM) microvasculature may possess a crucial role in the maintenance of homeostasis of BM due to mutual interactions between BM microvascular system and other physiological functions including haematopoiesis and osteogenesis. Chemotherapy...
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Shifting paradigm of cancer diagnoses in clinically relevant samples based on miniaturized electrochemical nanobiosensors and microfluidic devices
 
Publication date: 15 February 2018Source:Biosensors and Bioelectronics, Volume 100 Author(s):...
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Aptamer-based hydrogel barcodes for the capture and detection of multiple types of pathogenic bacteria
 
Publication date: 15 February 2018Source:Biosensors and Bioelectronics, Volume 100 Author(s):...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Understanding and Communicating Measures of Treatment Effect on Survival: Can We Do Better?
 
AbstractTime-to-event end points are the most frequent primary end points in phase III oncology trials, both in the adjuvant and advanced settings. The evaluation of these end points is important to inform clinical practice. However, although different measures can be used to describe the effect of treatment...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Analysis of Postoperative Recurrence in Stage I–III Midgut Neuroendocrine Tumors
 
AbstractBackgroundSurgery represents the only curative treatment for stage I–III midgut neuroendocrine tumors (NETs). At present, there are very limited data on the risk of postoperative recurrence. The optimal modality, duration and frequency of surveillance have not been well established. In this work,...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma
 
AbstractBackgroundOne of the effects of oncogenic signaling is metabolic reprogramming of tumor cells to support anabolic growth, opening the way to therapeutic targeting of metabolic pathways.MethodsWe studied NAD biosynthesis in BRAF inhibitor (BRAFi)–resistant (BiR) melanoma cell lines. Data in cell...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer
 
AbstractBackgroundWe have previously shown that gene expression profiles of oral leukoplakia (OL) may improve the prediction of oral cancer (OC) risk. To identify new targets for prevention, we performed a systematic survey of transcripts associated with an increased risk of oral cancer and overexpressed...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
How Safe Are Various Systemic Therapies for Pediatric Psoriasis?
 
Reuters Health Information from Dermatology via xlomafota13 on Inoreader http://ift.tt/2fzdbty
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Chinese selective spending habits part II: Creating the desired lifestyle
 
We continued our conversation with Laurel Gu, Research Director, and Jessica Jin, Associate Beauty Director, both of Mintel, on the Chinese economy and how selective spending habits are causing a thought-provoking stir for brands.  from Aesthetics via xlomafota13 on Inoreader http://ift.tt/2k5mcvM
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Unilever Foundry invites South East Asian and Australasian startups to join its Foundry 30 SEAA community
 
Unilever’s platform for startups and innovators to engage, collaborate and explore business opportunities with Unilever and its 400-plus brand portfolio has launched its Foundry 30 SEAA community. from Aesthetics via xlomafota13 on Inoreader http://ift.tt/2k1C2aM
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
Shiseido research findings set to advance skin care
 
Japanese personal care heavyweight, Shiseido, succeeds in developing and applying two newly-advanced technologies: In Vivo visualisation of dermal capillaries and the involvement of vascular plexus malformation in hyperpigmentation. from Aesthetics via xlomafota13 on Inoreader http://ift.tt/2y8GfA1
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
L’Oreal founder’s daughter, Liliane Bettencourt, obituary
 
Liliane Bettencourt passed away last week, following decades of dedicated activity as a leader within the beauty and personal care industry. from Aesthetics via xlomafota13 on Inoreader http://ift.tt/2y9qDfp
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
MassDevice.com +5 | The top 5 medtech stories for September 27, 2017
 
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
The sex-shift in single disease and multimorbid asthma and rhinitis during puberty
 
Abstract BackgroundCross-sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear if this inequality changes after puberty. We examined the sex-specific prevalence of asthma and rhinitis as single and as multimorbid diseases before...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
The pruritogenic mediator endothelin-1 shifts the dendritic cell–T-cell response toward Th17/Th1 polarization
 
Abstract Endothelin-1 (ET-1) is associated with skin diseases such as atopic dermatitis (AD) and psoriasis. ET-1 is enhanced in the skin of AD and psoriasis patients. In addition, plasma levels of ET-1 are elevated in AD and psoriasis. Although both AD and psoriasis are T cell–mediated skin diseases,...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
EAACI Guidelines on Allergen Immunotherapy: IgE-mediated Food Allergy
 
Abstract Food allergy can result in considerable morbidity, impairment of quality of life and healthcare expenditure. There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy (FA-AIT) through the oral (OIT), sublingual (SLIT) or epicutaneous (EPIT)...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE
The prevalence of atopic dermatitis beyond childhood: A systematic review and meta-analysis of longitudinal studies
 
Abstract There are sparse and conflicting data regarding the long-term clinical course of atopic dermatitis (AD). Although often described as a primarily childhood disease, newer population-based estimates suggest the prevalence of pediatric and adult disease may be similar. Our objective was to determine...

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